Approaching a consensus cognitive battery for clinical trials in schizophrenia: The NIMH-MATRICS conference to select cognitive domains and test criteria

Michael F. Green; Keith H. Nuechterlein; James M. Gold; Deanna M. Barch; Jonathan Cohen; Susan Essock; Wayne S. Fenton; Fred Frese; Terry E. Goldberg; Robert K. Heaton; Richard S.E. Keefe; Robert S. Kern; Helena Kraemer; Ellen Stover; Daniel R. Weinberger; Steven Zalcman; Stephen R. Marder

doi:10.1016/j.biopsych.2004.06.023

Approaching a consensus cognitive battery for clinical trials in schizophrenia: The NIMH-MATRICS conference to select cognitive domains and test criteria

Michael F. Green, Keith H. Nuechterlein, James M. Gold, Deanna M. Barch, Jonathan Cohen, Susan Essock, Wayne S. Fenton, Fred Frese, Terry E. Goldberg, Robert K. Heaton, Richard S.E. Keefe, Robert S. Kern, Helena Kraemer, Ellen Stover, Daniel R. Weinberger, Steven Zalcman, Stephen R. Marder

Research output: Contribution to journal › Review article › peer-review

785 Scopus citations

Abstract

To stimulate the development of new drugs for the cognitive deficits of schizophrenia, the National Institute of Mental Health (NIMH) established the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative. This article presents an overview of decisions from the first MATRICS consensus conference. The goals of the meeting were to 1) identify the cognitive domains that should be represented in a consensus cognitive battery and 2) prioritize key criteria for selection of tests for the battery. Seven cognitive domains were selected based on a review of the literature and input from experts: working memory, attention/vigilance, verbal learning and memory, visual learning and memory, reasoning and problem solving, speed of processing, and social cognition. Based on discussions at this meeting, five criteria were considered essential for test selection: good test-retest reliability, high utility as a repeated measure, relationship to functional outcome, potential response to pharmacologic agents, and practicality/ tolerability. The results from this meeting constitute the initial steps for reaching a consensus cognitive battery for clinical trials in schizophrenia.

Original language	English
Pages (from-to)	301-307
Number of pages	7
Journal	Biological Psychiatry
Volume	56
Issue number	5
DOIs	https://doi.org/10.1016/j.biopsych.2004.06.023
State	Published - 1 Sep 2004
Externally published	Yes

Bibliographical note

Funding Information:
The conference “Identifying Cognitive Targets and Establishing Criteria for Test Selection” was supported by MH22006 Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS; SRM, MFG).

Funding

The conference “Identifying Cognitive Targets and Establishing Criteria for Test Selection” was supported by MH22006 Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS; SRM, MFG).

Funders	Funder number
MH22006 Measurement and Treatment Research
National Institute of Mental Health	Z01MH002716

Keywords

Cognition
cognitive assessment
cognitive enhancement
neurocognition
psychopharmacology
schizophrenia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.biopsych.2004.06.023

Cite this

Green, M. F., Nuechterlein, K. H., Gold, J. M., Barch, D. M., Cohen, J., Essock, S., Fenton, W. S., Frese, F., Goldberg, T. E., Heaton, R. K., Keefe, R. S. E., Kern, R. S., Kraemer, H., Stover, E., Weinberger, D. R., Zalcman, S., & Marder, S. R. (2004). Approaching a consensus cognitive battery for clinical trials in schizophrenia: The NIMH-MATRICS conference to select cognitive domains and test criteria. Biological Psychiatry, 56(5), 301-307. https://doi.org/10.1016/j.biopsych.2004.06.023

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abstract = "To stimulate the development of new drugs for the cognitive deficits of schizophrenia, the National Institute of Mental Health (NIMH) established the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative. This article presents an overview of decisions from the first MATRICS consensus conference. The goals of the meeting were to 1) identify the cognitive domains that should be represented in a consensus cognitive battery and 2) prioritize key criteria for selection of tests for the battery. Seven cognitive domains were selected based on a review of the literature and input from experts: working memory, attention/vigilance, verbal learning and memory, visual learning and memory, reasoning and problem solving, speed of processing, and social cognition. Based on discussions at this meeting, five criteria were considered essential for test selection: good test-retest reliability, high utility as a repeated measure, relationship to functional outcome, potential response to pharmacologic agents, and practicality/ tolerability. The results from this meeting constitute the initial steps for reaching a consensus cognitive battery for clinical trials in schizophrenia.",

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note = "Funding Information: The conference “Identifying Cognitive Targets and Establishing Criteria for Test Selection” was supported by MH22006 Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS; SRM, MFG). ",

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doi = "10.1016/j.biopsych.2004.06.023",

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Green, MF, Nuechterlein, KH, Gold, JM, Barch, DM, Cohen, J, Essock, S, Fenton, WS, Frese, F, Goldberg, TE, Heaton, RK, Keefe, RSE, Kern, RS, Kraemer, H, Stover, E, Weinberger, DR, Zalcman, S & Marder, SR 2004, 'Approaching a consensus cognitive battery for clinical trials in schizophrenia: The NIMH-MATRICS conference to select cognitive domains and test criteria', Biological Psychiatry, vol. 56, no. 5, pp. 301-307. https://doi.org/10.1016/j.biopsych.2004.06.023

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Approaching a consensus cognitive battery for clinical trials in schizophrenia: The NIMH-MATRICS conference to select cognitive domains and test criteria

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

Access to Document

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