TY - JOUR
T1 - Application of unlaminated EBT3 film dosimeter for quantification of dose enhancement using silver nanoparticle-embedded alginate film
AU - Kakade, Nitin R.
AU - Das, Abhishek
AU - Kumar, Rajesh
AU - Sharma, S. D.
AU - Chadha, Ridhima
AU - Maiti, Nandita
AU - Kapoor, Sudhir
N1 - Publisher Copyright:
© 2022 IOP Publishing Ltd.
PY - 2022/4/5
Y1 - 2022/4/5
N2 - Purpose. The paper describes the application of unlaminated Gafchromic EBT3 film dosimeter for quantification of dose enhancement using locally synthesized silver nanoparticle-embedded alginate film (AgNPs-Alg film) for nanoparticles-aided radiotherapy. Materials and Methods. AgNPs-Alg film was synthesized and characterized using standard techniques. The unlaminated Gafchromic EBT3 film was specially customized for dosimetric measurement. The dose enhancements due to AgNPs-Alg film was experimentally determined for ISO wide spectrum x-rays series (average energy ranging from 57-137 keV) and 6 and 10 MV x-rays using laminated and unlaminated Gafchromic EBT3 film. The radiation dose of 1 Gy was delivered to a combination of AgNPs-Alg films and EBT3 film. Results. Ultraviolet-Visible spectroscopy of silver nanoparticles shows a surface plasmon resonance peak at 400 nm. The average particle size of 13 ± 2 nm was measured using Atomic Force Microscopy. For unlaminated film, the dose enhancements of 29%, 23%, 14% and 2% was observed for ISO wide spectrum x-rays having average energy of 57, 79, 104 and 137 keV, respectively. The dose enhancement was negligible for 6 and 10 MV x-rays. In the case of laminated film, no significant dose enhancement was measured for all the x-ray energies. Conclusion. The unlaminated Gafchromic EBT3 film can be a suitable choice for the measurement of dose enhancement. Further, silver nanoparticles can be used during nanoparticle-aided radiotherapy when irradiated at low x-ray energy.
AB - Purpose. The paper describes the application of unlaminated Gafchromic EBT3 film dosimeter for quantification of dose enhancement using locally synthesized silver nanoparticle-embedded alginate film (AgNPs-Alg film) for nanoparticles-aided radiotherapy. Materials and Methods. AgNPs-Alg film was synthesized and characterized using standard techniques. The unlaminated Gafchromic EBT3 film was specially customized for dosimetric measurement. The dose enhancements due to AgNPs-Alg film was experimentally determined for ISO wide spectrum x-rays series (average energy ranging from 57-137 keV) and 6 and 10 MV x-rays using laminated and unlaminated Gafchromic EBT3 film. The radiation dose of 1 Gy was delivered to a combination of AgNPs-Alg films and EBT3 film. Results. Ultraviolet-Visible spectroscopy of silver nanoparticles shows a surface plasmon resonance peak at 400 nm. The average particle size of 13 ± 2 nm was measured using Atomic Force Microscopy. For unlaminated film, the dose enhancements of 29%, 23%, 14% and 2% was observed for ISO wide spectrum x-rays having average energy of 57, 79, 104 and 137 keV, respectively. The dose enhancement was negligible for 6 and 10 MV x-rays. In the case of laminated film, no significant dose enhancement was measured for all the x-ray energies. Conclusion. The unlaminated Gafchromic EBT3 film can be a suitable choice for the measurement of dose enhancement. Further, silver nanoparticles can be used during nanoparticle-aided radiotherapy when irradiated at low x-ray energy.
KW - dose enhancement factor
KW - nanoparticles
KW - radiotherapy
KW - unlaminated EBT3 film
UR - http://www.scopus.com/inward/record.url?scp=85128159765&partnerID=8YFLogxK
U2 - 10.1088/2057-1976/ac60c5
DO - 10.1088/2057-1976/ac60c5
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C2 - 35325874
AN - SCOPUS:85128159765
SN - 2057-1976
VL - 8
JO - Biomedical Physics and Engineering Express
JF - Biomedical Physics and Engineering Express
IS - 3
M1 - 035014
ER -