TY - JOUR
T1 - Antiviral Treatment and Risk of Hearing Loss in Asymptomatic and Mild Symptomatic Infants With Congenital Cytomegalovirus
AU - behalf of the cCMVnet Registry Study Group
AU - Villaverde, Serena
AU - Pedrero-Tomé, Roberto
AU - Papaevangelou, Vassiliki
AU - Syridou, Garyfallia
AU - Karagiannidou, Sofia
AU - Lyall, Hermione
AU - Payne, Helen
AU - Frick, Marie Antoinette
AU - Soler-Palacín, Pere
AU - Baquero-Artigao, Fernando
AU - Rodríguez-Molino, Paula
AU - Fortuny-Guasch, Claudia
AU - Rios-Barnés, Maria
AU - Sánchez-Mateos, Miguel
AU - Saavedra-Lozano, Jesús
AU - Bringué, Xavier
AU - Moliner, Elisenda
AU - Castells, Laura
AU - Muga, Oihana
AU - Vives-Oños, Isabel
AU - Gkentzi, Despoina
AU - Lombardi, Giuseppina
AU - Tagarro, Alfredo
AU - Colino, Elena
AU - Couceiro, Jose A.
AU - Rojo, Pablo
AU - de Vergas, Joaquín
AU - Blázquez-Gamero, Daniel
AU - Abu-Bakar, A.
AU - Agúndez-Reigosa, B.
AU - Alexander, E.
AU - Alfonso-Rodríguez, O.
AU - Alonso-Ojembarrena, A.
AU - Álvarez-Breciano, F.
AU - Álvarez-Vallejo, B.
AU - Angelini, M.
AU - Ansary, A.
AU - Ara-Montojo, F.
AU - Bamford, A.
AU - Bandi, S.
AU - Barja-Tur, J.
AU - Beceiro, J.
AU - Belén-Jiménez, A.
AU - Benou, S.
AU - Berghuis, D.
AU - Bhagwandas, K.
AU - Bolchová, J.
AU - Bonil-Martínez, V.
AU - Borgstein, B.
AU - Glikman, D.
N1 - Publisher Copyright:
Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2025/3/1
Y1 - 2025/3/1
N2 - Background: To assess hearing outcomes at 24 months of age in infants with mild congenital cytomegalovirus (cCMV) infection, depending on whether they have received antiviral treatment or not. Methods: A retrospective study within the European Registry of Children with cCMV was performed. Included children had cCMV diagnosed in utero/in the first 21 days of life, with normal physical examination, alanine aminotransferase <80 U/L and platelets >100,000 cs/mm3 and absence of hearing loss (HL) at birth. Cranial ultrasound (cUS) and/or cranial magnetic resonance imaging was normal or with minor findings (isolated lenticulostriate vasculopathy and/or germinolysis/caudothalamic or subependymal cysts, and/or focal/multifocal white matter involvement). The main outcome was the presence of HL at 24 months of age. Results: One hundred ninety-six patients met inclusion criteria. A total of 34.7% received antiviral treatment with valganciclovir/ganciclovir. Children treated had lower gestational age, birth weight and head circumference, and maternal primary infection was less frequent. Among treated children, 21.3% presented minor findings in cUS versus 6.3% in nontreatment group (P = 0.003). Nine patients (4.6%) developed HL at 24 months. Among children with HL, 20% presented minor findings in cUS versus 11.3% in non-HL group (P = NS). HL rate was similar in treated and nontreated groups (4.6% vs. 6.3%; P = 0.6). Conclusions: One-third of the children were treated with antivirals and infants with minor neuroimaging findings at birth were more likely to receive antiviral. There were no differences in the prevalence of HL at 2 years of age between treated and not-treated children. Minor neuroimaging findings were not clearly associated with an increased risk of delayed onset HL.
AB - Background: To assess hearing outcomes at 24 months of age in infants with mild congenital cytomegalovirus (cCMV) infection, depending on whether they have received antiviral treatment or not. Methods: A retrospective study within the European Registry of Children with cCMV was performed. Included children had cCMV diagnosed in utero/in the first 21 days of life, with normal physical examination, alanine aminotransferase <80 U/L and platelets >100,000 cs/mm3 and absence of hearing loss (HL) at birth. Cranial ultrasound (cUS) and/or cranial magnetic resonance imaging was normal or with minor findings (isolated lenticulostriate vasculopathy and/or germinolysis/caudothalamic or subependymal cysts, and/or focal/multifocal white matter involvement). The main outcome was the presence of HL at 24 months of age. Results: One hundred ninety-six patients met inclusion criteria. A total of 34.7% received antiviral treatment with valganciclovir/ganciclovir. Children treated had lower gestational age, birth weight and head circumference, and maternal primary infection was less frequent. Among treated children, 21.3% presented minor findings in cUS versus 6.3% in nontreatment group (P = 0.003). Nine patients (4.6%) developed HL at 24 months. Among children with HL, 20% presented minor findings in cUS versus 11.3% in non-HL group (P = NS). HL rate was similar in treated and nontreated groups (4.6% vs. 6.3%; P = 0.6). Conclusions: One-third of the children were treated with antivirals and infants with minor neuroimaging findings at birth were more likely to receive antiviral. There were no differences in the prevalence of HL at 2 years of age between treated and not-treated children. Minor neuroimaging findings were not clearly associated with an increased risk of delayed onset HL.
KW - antiviral
KW - congenital
KW - cytomegalovirus
KW - hearing loss
UR - https://www.scopus.com/pages/publications/85210162270
U2 - 10.1097/INF.0000000000004583
DO - 10.1097/INF.0000000000004583
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 39383383
AN - SCOPUS:85210162270
SN - 0891-3668
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
M1 - 10.1097/INF.0000000000004583
ER -
SDG 3 Good Health and Well-being