TY - JOUR
T1 - Anti‐VEGF‐Aptamer Modified C‐Dots—A Hybrid Nanocomposite for Topical Treatment of Ocular Vascular Disorders,
AU - Shoval, Asaf
AU - Markus, Amos
AU - Zhou, Zhixin
AU - Liu, Xia
AU - Cazelles, R'emi
AU - Willner, Itamar
AU - Mandel, Yossi
PY - 2019
Y1 - 2019
N2 - The vascular endothelial growth factor (VEGF) induces pathological angiogenetic ocular diseases. It is a scientific challenge to develop carriers for the controlled release of inhibitors for VEGF present in the back of the eye domain. Carbon dots (C-dots) functionalized with the VEGF aptamer are introduced and the hybrid nanoparticles are used for ocular nanomedicine. The C-dots are applied as effective carriers of the anti-VEGF aptamer across the cornea, yielding therapeutic levels upon topical administration. The hybrids show no toxicity for both in vitro and in vivo murine animal model, and further enable noninvasive intraocular concentration monitoring through the C-dots inherent fluorescence. In addition, the hybrid C-dots effectively inhibit VEGF-stimulated angiogenesis in choroidal blood vessels. This inhibition is comparable to two commercially available anti-VEGF drugs, bevacizumab and aflibercept. The hybrid aptamer-modified C-dots provide a versatile nanomaterial to treat age-related macular degeneration and diabetic retinopathy.,
AB - The vascular endothelial growth factor (VEGF) induces pathological angiogenetic ocular diseases. It is a scientific challenge to develop carriers for the controlled release of inhibitors for VEGF present in the back of the eye domain. Carbon dots (C-dots) functionalized with the VEGF aptamer are introduced and the hybrid nanoparticles are used for ocular nanomedicine. The C-dots are applied as effective carriers of the anti-VEGF aptamer across the cornea, yielding therapeutic levels upon topical administration. The hybrids show no toxicity for both in vitro and in vivo murine animal model, and further enable noninvasive intraocular concentration monitoring through the C-dots inherent fluorescence. In addition, the hybrid C-dots effectively inhibit VEGF-stimulated angiogenesis in choroidal blood vessels. This inhibition is comparable to two commercially available anti-VEGF drugs, bevacizumab and aflibercept. The hybrid aptamer-modified C-dots provide a versatile nanomaterial to treat age-related macular degeneration and diabetic retinopathy.,
UR - http://www.ncbi.nlm.nih.gov/pubmed/31402576 https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.201902776,
UR - http://scholar.google.com/scholar?num=3&hl=en&lr=&q=allintitle%3A%20Anti%E2%80%90VEGF%E2%80%90Aptamer%20Modified%20C%E2%80%90Dots%E2%80%94A%20Hybrid%20Nanocomposite%20for%20Topical%20Treatment%20of%20Ocular%20Vascular%20Disorders%2C%20author%3AAsaf%20OR%20author%3AShoval%20OR%20author%3AAmos%20OR%20author%3AMarkus%20OR%20author%3AZhixin%20OR%20author%3AZhou%20OR%20author%3AXia%20OR%20author%3ALiu%20OR%20author%3AR%5Cemi%20OR%20author%3ACazelles%20OR%20author%3AItamar%20OR%20author%3AWillner%20OR%20author%3AYossi%20OR%20author%3AMandel&as_ylo=2019&as_yhi=&btnG=Search&as_vis=0
M3 - Article
SP - 1902776
JO - Small,
JF - Small,
ER -
