Antiproliferative potency of novel benzofuran-2-carboxamides on tumour cell lines: Cell death mechanisms and determination of crystal structure

Marijana Hranjec, Irena Sović, Ivana Ratkaj, Gordana Pavlović, Nataša Ilić, Linda Valjalo, Krešimir Pavelić, Sandra Kraljević Pavelić, Grace Karminski-Zamola

Research output: Contribution to journalArticlepeer-review

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Abstract

In this manuscript the synthesis and biological activity of novel heterocyclic derivatives of benzofuran-2-carboxamides 3a-j and 6a-f is presented. Biological evaluation in vitro revealed that only few compounds exerted concentration-depended antiproliferative effects on tumour cell lines at micromolar concentrations. In particular, 2-imidazolynyl substituted compound 6f showed selectivity on SK-BR-3 cell line while 2-N-acetamidopyridyl substituted 3h and 2-imidazolynyl substituted amide 3i showed selective concentration-dependent antiproliferative effects on SW620 cell line. Compounds 3h and 6f induced apoptosis while compound 3i acted through a cell death mechanism other than apoptosis.

Original languageEnglish
Pages (from-to)111-119
Number of pages9
JournalEuropean Journal of Medicinal Chemistry
Volume59
DOIs
StatePublished - Jan 2013
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by the Croatian Ministry of Science, Education and Sports (grant numbers: 125-0982464-1356 , 098-1191344-2943 , 335-0982464-2393 , 335-0000000-3532 ).

Funding

This work was supported by the Croatian Ministry of Science, Education and Sports (grant numbers: 125-0982464-1356 , 098-1191344-2943 , 335-0982464-2393 , 335-0000000-3532 ).

FundersFunder number
Croatian Ministry of Science, Education and Sports125-0982464-1356, 335-0000000-3532, 335-0982464-2393, 098-1191344-2943

    Keywords

    • Antiproliferative activity
    • Apoptosis
    • Benzofuranes
    • Carboxamides
    • Crystal structure determination

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