Antioxidants attenuate endotoxin-induced acute renal failure in rats

Yehuda Zurovsky, Iris Gispaan

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Acute kidney dysfunction, manifested by a reduction in renal blood flow and in the glomerular filtration rate, is a common finding in septic shock. The pathogenetic mechanisms responsible for the renal dysfunction observed in the endotoxemic murine model are not completely understood. In this study, an attempt was made to halt the progressive renal dysfunction in the rats by administration of the antioxidants dimethylthiourea (DMTU) (50 mg/100 g) and superoxide dismutase (SOD) (0.4 mg/100 g) before endotoxin infusion (0.5 mg/100 g), or by inducing endotoxin tolerance. Renal function, assessed by creatinine, inulin, and p-aminohippuric acid clearance, nicotinamide adenine dinucleotide, and electrolyte reabsorption, was measured 4 hours after the endotoxin infusion. Renal function declined in all rats throughout the study period. However, the reduction in renal function was markedly slower in endotoxemic rats administered DMTU and SOD compared with untreated rats. Similar results were found following induction of endotoxin tolerance. These data suggest that DMTU, SOD, and endotoxin tolerance may be potentially beneficial in halting progressive renal damage associated with endotoxemia.

Original languageEnglish
Pages (from-to)51-57
Number of pages7
JournalAmerican Journal of Kidney Diseases
Volume25
Issue number1
DOIs
StatePublished - Jan 1995

Bibliographical note

Funding Information:
August I, 1994. Supported in part by the Health Sciences Research Center, Bar-Ran University, and a grant from the Chief Scientist of the Ministry of Health, Israel. Address reprint requests to Yehuda Zurovshy, partment of Lijie Sciences, Bar-Ran University, 52900 Israel. 0 1995 by the National Kidney Foundation, 0272-6386/95L?SOl-0010$3.00/0

Funding

August I, 1994. Supported in part by the Health Sciences Research Center, Bar-Ran University, and a grant from the Chief Scientist of the Ministry of Health, Israel. Address reprint requests to Yehuda Zurovshy, partment of Lijie Sciences, Bar-Ran University, 52900 Israel. 0 1995 by the National Kidney Foundation, 0272-6386/95L?SOl-0010$3.00/0

FundersFunder number
Bar-Ran University
Health Sciences Research Center
Ministry of Health, State of Israel

    Keywords

    • Antioxidant
    • dimethylthiourea
    • endotoxin
    • endotoxin tolerance
    • superoxide dismutase

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