Antioxidant activity of 1,3-dicaffeoylquinic acid isolated from Inula viscosa

Ortal Danino, Hugo E. Gottlieb, Shlomo Grossman, Margalit Bergman

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Inula viscosa is a perennial herbaceous plant used topically in folk medicine as an anti-scabies, anti-inflammatory, and wound-healing agent. We examined the antioxidant activity of the methanolic extract of I. viscosa. We isolated and identified several polyphenolic antioxidants from I. viscosa leaves and focused on 1,3-dicaffeoylquinic acid (1,3-diCQA). Antioxidant activity was measured using ABTS and DPPH assays, which measure antioxidant activity. The concentrations of 1,3-diCQA required for the inhibition of oxidation were lower than those required by other known antioxidants. 1,3-diCQA inhibited oxidative damage caused by various factors, including FeSO4 and AAPH (2,2′-azobis(2-amidinopropane) dehydrochloride). Antioxidant activity can also be detected by the ability of a compound to scavenge reactive oxygen species (ROS). 1,3-diCQA was found to scavenge hydroxyl radical and superoxide radicals, as measured by electron spin resonance (ESR). These data demonstrate that 1,3-diCQA exhibits antioxidant properties, probably through the involvement of a direct scavenging effect on several free radicals.

Original languageEnglish
Pages (from-to)1273-1280
Number of pages8
JournalFood Research International
Issue number9
StatePublished - Nov 2009

Bibliographical note

Funding Information:
This research was partly supported by the Vinograd Foundation and the Lewitt–Schwartz Chair.


  • Antioxidant activity
  • Caffeoylquinic acid
  • Dicaffeoylquinic acid
  • Inula viscosa
  • ROS


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