Antioxidant activity of 1,3-dicaffeoylquinic acid isolated from Inula viscosa

Ortal Danino, Hugo E. Gottlieb, Shlomo Grossman, Margalit Bergman

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Abstract

Inula viscosa is a perennial herbaceous plant used topically in folk medicine as an anti-scabies, anti-inflammatory, and wound-healing agent. We examined the antioxidant activity of the methanolic extract of I. viscosa. We isolated and identified several polyphenolic antioxidants from I. viscosa leaves and focused on 1,3-dicaffeoylquinic acid (1,3-diCQA). Antioxidant activity was measured using ABTS and DPPH assays, which measure antioxidant activity. The concentrations of 1,3-diCQA required for the inhibition of oxidation were lower than those required by other known antioxidants. 1,3-diCQA inhibited oxidative damage caused by various factors, including FeSO4 and AAPH (2,2′-azobis(2-amidinopropane) dehydrochloride). Antioxidant activity can also be detected by the ability of a compound to scavenge reactive oxygen species (ROS). 1,3-diCQA was found to scavenge hydroxyl radical and superoxide radicals, as measured by electron spin resonance (ESR). These data demonstrate that 1,3-diCQA exhibits antioxidant properties, probably through the involvement of a direct scavenging effect on several free radicals.

Original languageEnglish
Pages (from-to)1273-1280
Number of pages8
JournalFood Research International
Volume42
Issue number9
DOIs
StatePublished - Nov 2009

Bibliographical note

Funding Information:
This research was partly supported by the Vinograd Foundation and the Lewitt–Schwartz Chair.

Funding

This research was partly supported by the Vinograd Foundation and the Lewitt–Schwartz Chair.

FundersFunder number
Vinograd Foundation

    Keywords

    • Antioxidant activity
    • Caffeoylquinic acid
    • Dicaffeoylquinic acid
    • Inula viscosa
    • ROS

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