Antimicrobial peptides and the skin and gut microbiomes

Adrienne Joseph, Meital Nuriel-Ohayon, Shai Bel, Tamia A. Harris

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Animals are in constant contact with the microbial world. These interactions include fending off potential pathogens and also maintaining a beneficial relationship with the microbiome. An evolutionarily conserved and widespread mechanism of achieving this balance is the production and secretion of antimicrobial peptides (AMPs). AMPs are short proteins produced at different sites that either kill or inhibit bacterial contact with the host. Here, we review the different AMP families that are expressed in the skin and intestine. We review their mechanisms of action and their regulation by the host. We further discuss the involvement of AMPs in human diseases and their potential use as therapeutics.

Original languageEnglish
Title of host publicationPeptide and Peptidomimetic Therapeutics
Subtitle of host publicationFrom Bench to Bedside
Number of pages18
ISBN (Electronic)9780128201411
ISBN (Print)9780128204474
StatePublished - 1 Jan 2022

Bibliographical note

Publisher Copyright:
© 2022 Elsevier Inc. All rights reserved.


  • Antimicrobial peptides
  • microbiome


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