Antimicrobial compositions and methods and uses thereof

The invention relates to inhibitors of a bacterial biofilm formation that target the N′ loop extension of the periplasmic subunit of a bacterial Phosphate Specific Transfer system (PstS), specifically, of P. aeruginosa. The inhibitors of the invention may be either derived from the N′ loop extension of PstS or directed against the N′ loop extension. The invention further provides compositions and methods using said inhibitors in inhibiting biofilm formation and in treating pathologic conditions associated therewith.