Antimicrobial Activities of Zn-Doped CuO Microparticles Decorated on Polydopamine against Sensitive and Antibiotic-Resistant Bacteria

Moorthy Maruthapandi; Arumugam Saravanan; Poushali Das; Michal Natan; Gila Jacobi; Ehud Banin; John H.T. Luong; Aharon Gedanken

doi:10.1021/acsapm.0c01104

Antimicrobial Activities of Zn-Doped CuO Microparticles Decorated on Polydopamine against Sensitive and Antibiotic-Resistant Bacteria

Moorthy Maruthapandi, Arumugam Saravanan, Poushali Das, Michal Natan, Gila Jacobi, Ehud Banin, John H.T. Luong, Aharon Gedanken

University College Cork

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

A polydopamine (PDA) composite was synthesized by depositing Zn-doped CuO (Zn@CuO) particles on polydopamine by one-step ultrasonication. XPS, XRD, and FTIR confirmed the formation of spherical Zn@CuO on PDA with resulting diameters ranging from 1 to 5 μm. The PDA-Zn@CuO at 0.125-0.5 mg/mL exhibited a superior activity over Zn@CuO against sensitive and antibiotic-resistant bacteria. The Zn@CuO nanosized hybrid particles could penetrate the cell but interacted less effectively with bacterial biomolecules to provoke rapid cell lysis. PDA above 0.5 mg/mL also had a modest effect against Escherichia coli and Staphylococcus aureus. However, much higher PDA concentrations were required to restrict the flow of essential nutrients and wastes in and out of the cytoplasmic matrix and resulted in eventual cell death. The binding of PDA-Zn@CuO to bacteria played an important role in causing bacterial death, whereas reactive oxygen species (ROS) also effectively contributed to cell killing.

Original language	English
Pages (from-to)	5878-5888
Number of pages	11
Journal	ACS Applied Polymer Materials
Volume	2
Issue number	12
DOIs	https://doi.org/10.1021/acsapm.0c01104
State	Published - 11 Dec 2020

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Publisher Copyright:
©

Keywords

PDA
PDA-Zn@CuO
Zn@CuO
antibiotic-resistant bacteria
sensitive bacteria

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10.1021/acsapm.0c01104

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title = "Antimicrobial Activities of Zn-Doped CuO Microparticles Decorated on Polydopamine against Sensitive and Antibiotic-Resistant Bacteria",

abstract = "A polydopamine (PDA) composite was synthesized by depositing Zn-doped CuO (Zn@CuO) particles on polydopamine by one-step ultrasonication. XPS, XRD, and FTIR confirmed the formation of spherical Zn@CuO on PDA with resulting diameters ranging from 1 to 5 μm. The PDA-Zn@CuO at 0.125-0.5 mg/mL exhibited a superior activity over Zn@CuO against sensitive and antibiotic-resistant bacteria. The Zn@CuO nanosized hybrid particles could penetrate the cell but interacted less effectively with bacterial biomolecules to provoke rapid cell lysis. PDA above 0.5 mg/mL also had a modest effect against Escherichia coli and Staphylococcus aureus. However, much higher PDA concentrations were required to restrict the flow of essential nutrients and wastes in and out of the cytoplasmic matrix and resulted in eventual cell death. The binding of PDA-Zn@CuO to bacteria played an important role in causing bacterial death, whereas reactive oxygen species (ROS) also effectively contributed to cell killing.",

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author = "Moorthy Maruthapandi and Arumugam Saravanan and Poushali Das and Michal Natan and Gila Jacobi and Ehud Banin and Luong, {John H.T.} and Aharon Gedanken",

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doi = "10.1021/acsapm.0c01104",

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AU - Maruthapandi, Moorthy

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AU - Das, Poushali

AU - Natan, Michal

AU - Jacobi, Gila

AU - Banin, Ehud

AU - Luong, John H.T.

AU - Gedanken, Aharon

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N2 - A polydopamine (PDA) composite was synthesized by depositing Zn-doped CuO (Zn@CuO) particles on polydopamine by one-step ultrasonication. XPS, XRD, and FTIR confirmed the formation of spherical Zn@CuO on PDA with resulting diameters ranging from 1 to 5 μm. The PDA-Zn@CuO at 0.125-0.5 mg/mL exhibited a superior activity over Zn@CuO against sensitive and antibiotic-resistant bacteria. The Zn@CuO nanosized hybrid particles could penetrate the cell but interacted less effectively with bacterial biomolecules to provoke rapid cell lysis. PDA above 0.5 mg/mL also had a modest effect against Escherichia coli and Staphylococcus aureus. However, much higher PDA concentrations were required to restrict the flow of essential nutrients and wastes in and out of the cytoplasmic matrix and resulted in eventual cell death. The binding of PDA-Zn@CuO to bacteria played an important role in causing bacterial death, whereas reactive oxygen species (ROS) also effectively contributed to cell killing.

AB - A polydopamine (PDA) composite was synthesized by depositing Zn-doped CuO (Zn@CuO) particles on polydopamine by one-step ultrasonication. XPS, XRD, and FTIR confirmed the formation of spherical Zn@CuO on PDA with resulting diameters ranging from 1 to 5 μm. The PDA-Zn@CuO at 0.125-0.5 mg/mL exhibited a superior activity over Zn@CuO against sensitive and antibiotic-resistant bacteria. The Zn@CuO nanosized hybrid particles could penetrate the cell but interacted less effectively with bacterial biomolecules to provoke rapid cell lysis. PDA above 0.5 mg/mL also had a modest effect against Escherichia coli and Staphylococcus aureus. However, much higher PDA concentrations were required to restrict the flow of essential nutrients and wastes in and out of the cytoplasmic matrix and resulted in eventual cell death. The binding of PDA-Zn@CuO to bacteria played an important role in causing bacterial death, whereas reactive oxygen species (ROS) also effectively contributed to cell killing.

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Antimicrobial Activities of Zn-Doped CuO Microparticles Decorated on Polydopamine against Sensitive and Antibiotic-Resistant Bacteria

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