Antigen Receptor Diversification during immune responses

R. Mehr; M. Michaeli

doi:10.1201/9781315119847

Antigen Receptor Diversification during immune responses

R. Mehr
, M. Michaeli

The Mina and Everard Goodman Faculty of Life Sciences - at Bar-Ilan University

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The fact that most immunoglobulin variable region (IgV) genes sampled are heavily mutated poses, on one hand, a challenge that must be overcome when processing IgV gene sequencing data. On the other hand, many analysis methods based on identifying these mutations can yield very useful insights regarding B cell clonal dynamics and antigen-driven selection. This chapter reviews the problems and solutions posed by SHM, the SHM-based analysis methods, and some insights gleaned from these analyses.

Original language	English
Title of host publication	Systems Immunology
Subtitle of host publication	An Introduction to Modeling Methods for Scientists
Editors	J. Das, C. Jayaprakash
Publisher	CRC Press
Chapter	12
Number of pages	14
Edition	1
ISBN (Electronic)	9781315119847
DOIs	https://doi.org/10.1201/9781315119847
State	E-pub ahead of print - 15 Sep 2017

Access to Document

10.1201/9781315119847

Cite this

@inbook{4f0e5f5c0db14d8c81bc78645b8b225d,

title = "Antigen Receptor Diversification during immune responses",

abstract = "The fact that most immunoglobulin variable region (IgV) genes sampled are heavily mutated poses, on one hand, a challenge that must be overcome when processing IgV gene sequencing data. On the other hand, many analysis methods based on identifying these mutations can yield very useful insights regarding B cell clonal dynamics and antigen-driven selection. This chapter reviews the problems and solutions posed by SHM, the SHM-based analysis methods, and some insights gleaned from these analyses.",

author = "R. Mehr and M. Michaeli",

year = "2017",

month = sep,

day = "15",

doi = "10.1201/9781315119847",

language = "אנגלית",

editor = "J. Das and C. Jayaprakash",

booktitle = "Systems Immunology",

publisher = "CRC Press",

edition = "1",

}

TY - CHAP

T1 - Antigen Receptor Diversification during immune responses

AU - Mehr, R.

AU - Michaeli, M.

PY - 2017/9/15

Y1 - 2017/9/15

N2 - The fact that most immunoglobulin variable region (IgV) genes sampled are heavily mutated poses, on one hand, a challenge that must be overcome when processing IgV gene sequencing data. On the other hand, many analysis methods based on identifying these mutations can yield very useful insights regarding B cell clonal dynamics and antigen-driven selection. This chapter reviews the problems and solutions posed by SHM, the SHM-based analysis methods, and some insights gleaned from these analyses.

AB - The fact that most immunoglobulin variable region (IgV) genes sampled are heavily mutated poses, on one hand, a challenge that must be overcome when processing IgV gene sequencing data. On the other hand, many analysis methods based on identifying these mutations can yield very useful insights regarding B cell clonal dynamics and antigen-driven selection. This chapter reviews the problems and solutions posed by SHM, the SHM-based analysis methods, and some insights gleaned from these analyses.

UR - https://www.taylorfrancis.com/chapters/edit/10.1201/9781315119847-12/antigen-receptor-diversification-immune-responses-miri-michaeli-ramit-mehr

U2 - 10.1201/9781315119847

DO - 10.1201/9781315119847

M3 - ???researchoutput.researchoutputtypes.contributiontobookanthology.chapter???

BT - Systems Immunology

A2 - Das, J.

A2 - Jayaprakash, C.

PB - CRC Press

ER -

Antigen Receptor Diversification during immune responses

Abstract

Access to Document

Other files and links

Fingerprint

Cite this