Antibiotics increase aggression behavior and aggression-related pheromones and receptors in Drosophila melanogaster

M. Grinberg; R. Levin; H. Neuman; O. Ziv; S. Turjeman; Gila Gamliel; R. Nosenko; O. Koren

doi:10.1016/j.isci.2022.104371

Antibiotics increase aggression behavior and aggression-related pheromones and receptors in Drosophila melanogaster

M. Grinberg
, R. Levin
, H. Neuman
, O. Ziv
, S. Turjeman
, Gila Gamliel
, R. Nosenko
, O. Koren

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Aggression is a behavior common in most species; it is controlled by internal and external drivers, including hormones, environmental cues, and social interactions, and underlying pathways are understood in a broad range of species. To date, though, effects of gut microbiota on aggression in the context of gut-brain communication and social behavior have not been completely elucidated. We examine how manipulation of Drosophila melanogaster microbiota affects aggression as well as the pathways that underlie the behavior in this species. Male flies treated with antibiotics exhibited significantly more aggressive behaviors. Furthermore, they had higher levels of cVA and (Z)-9 Tricosene, pheromones associated with aggression in flies, as well as higher expression of the relevant pheromone receptors and transporters OR67d, OR83b, GR32a, and LUSH. These findings suggest that aggressive behavior is, at least in part, mediated by bacterial species in flies.

Original language	English
Article number	104371
Journal	iScience
Volume	25
Issue number	6
DOIs	https://doi.org/10.1016/j.isci.2022.104371
State	Published - 17 Jun 2022

Bibliographical note

Publisher Copyright:
© 2022 The Author(s)

Funding

We thank members of the Koren laboratory, past and present, for professional help and critical thinking and the Zabam members for help with the GC-MS. This study was funded by the European Research Council Consolidator grant (grant agreement no. 101001355 ) and the Israel Science Foundation , grant numbers 2459/15 and 1001/16 .

Funders	Funder number
Horizon 2020 Framework Programme	101001355
European Commission
Israel Science Foundation	1001/16, 2459/15

Keywords

behavioral neuroscience
microbiome

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10.1016/j.isci.2022.104371

Cite this

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abstract = "Aggression is a behavior common in most species; it is controlled by internal and external drivers, including hormones, environmental cues, and social interactions, and underlying pathways are understood in a broad range of species. To date, though, effects of gut microbiota on aggression in the context of gut-brain communication and social behavior have not been completely elucidated. We examine how manipulation of Drosophila melanogaster microbiota affects aggression as well as the pathways that underlie the behavior in this species. Male flies treated with antibiotics exhibited significantly more aggressive behaviors. Furthermore, they had higher levels of cVA and (Z)-9 Tricosene, pheromones associated with aggression in flies, as well as higher expression of the relevant pheromone receptors and transporters OR67d, OR83b, GR32a, and LUSH. These findings suggest that aggressive behavior is, at least in part, mediated by bacterial species in flies.",

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AU - Levin, R.

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AU - Ziv, O.

AU - Turjeman, S.

AU - Gamliel, Gila

AU - Nosenko, R.

AU - Koren, O.

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AB - Aggression is a behavior common in most species; it is controlled by internal and external drivers, including hormones, environmental cues, and social interactions, and underlying pathways are understood in a broad range of species. To date, though, effects of gut microbiota on aggression in the context of gut-brain communication and social behavior have not been completely elucidated. We examine how manipulation of Drosophila melanogaster microbiota affects aggression as well as the pathways that underlie the behavior in this species. Male flies treated with antibiotics exhibited significantly more aggressive behaviors. Furthermore, they had higher levels of cVA and (Z)-9 Tricosene, pheromones associated with aggression in flies, as well as higher expression of the relevant pheromone receptors and transporters OR67d, OR83b, GR32a, and LUSH. These findings suggest that aggressive behavior is, at least in part, mediated by bacterial species in flies.

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Antibiotics increase aggression behavior and aggression-related pheromones and receptors in Drosophila melanogaster

Abstract

Bibliographical note

Funding

Keywords

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