Antibacterial effect of composite resins containing quaternary ammonium polyethyleneimine nanoparticles

Ira Yudovin-Farber, Nurit Beyth, Ervin I. Weiss, Abraham J. Domb

Research output: Contribution to journalArticlepeer-review

109 Scopus citations

Abstract

Quaternary ammonium polyethyleneimine (QA-PEI)-based nanoparticles were synthesized by crosslinking with dibromopentane followed by N-alkylation with various alkyl halides and further N-methylation with methyl iodide. Insoluble pyridinium-type particles were prepared by suspension polymerization of 4-vinyl pyridine followed by N-alkylation with alkyl halides. Polyamine-based nanoparticles embedded in restorative composite resin at 1% w/w were tested for antibacterial activity against Streptococcus mutans using direct contact test. Activity analysis revealed that the alkyl chain length of the QA-PEI nanoparticles plays a significant role in antibacterial activity of the reagent. The most potent compound was octyl-alkylated QA-PEI embedded in restorative composite resin at 1% w/w that totally inhibited S. mutans growth in 3-monthaged samples. This data indicates that restorative composite resin with antibacterial properties can be produced by the incorporation of QA-PEI nanoparticles.

Original languageEnglish
Pages (from-to)591-603
Number of pages13
JournalJournal of Nanoparticle Research
Volume12
Issue number2
DOIs
StatePublished - 2010
Externally publishedYes

Keywords

  • Antibacterial
  • EHS
  • Nanomedicine
  • Nanoparticles
  • Polycations
  • Quaternary ammonium polyethyleneimine
  • Restorative composite resin

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