Anti-Phospholipase A2 Receptor Autoantibodies

Monalyn De Los Reyes Labitigan, Chaim Putterman

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Anti-phospholipase A2 receptor (anti-PLA2R) autoantibodies were first described in 2009 and implicated in the pathogenesis of idiopathic membranous nephritis (IMN). This was a significant advance given that until then, the pathogenesis of IMN was unclear and differentiation from secondary membranous nephritis could be challenging. Since this initial study describing the anti-PLA2R antibody, several other investigators have confirmed the association of this autoantibody with IMN. Furthermore, anti-PLA2R antibodies correlate with clinical outcomes and can be used to measure response to treatment. Therefore, anti-PLA2R autoantibodies have promising applications to the diagnosis, monitoring, and treatment of IMN.

Original languageEnglish
Title of host publicationAutoantibodies, Third Edition
PublisherElsevier
Pages545-552
Number of pages8
ISBN (Electronic)9780444563781
ISBN (Print)9780444593771
DOIs
StatePublished - 1 Jan 2014
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2014 Elsevier B.V. All rights reserved.

Keywords

  • Anti-phospholipase A2 receptor antibodies
  • lupus nephritis
  • membranous nephropathy
  • phospholipase A2 receptor
  • podocytes
  • systemic lupus erythematosus

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