Anti-oxidant potential of plants and probiotic spp. in alleviating oxidative stress induced by H2O2

Harsh Kumar, Rajni Dhalaria, Shivani Guleria, Richard Cimler, Ruchi Sharma, Shahida Anusha Siddiqui, Marian Valko, Eugenie Nepovimova, Daljeet Singh Dhanjal, Reena Singh, Vijay Kumar, Ashok Kumar Pathera, Narinder Verma, Talwinder Kaur, Sivakumar Manickam, Suliman Y. Alomar, Kamil Kuča

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Cells produce reactive oxygen species (ROS) as a metabolic by-product. ROS molecules trigger oxidative stress as a feedback response that significantly initiates biological processes such as autophagy, apoptosis, and necrosis. Furthermore, extensive research has revealed that hydrogen peroxide (H2O2) is an important ROS entity and plays a crucial role in several physiological processes, including cell differentiation, cell signalling, and apoptosis. However, excessive production of H2O2 has been shown to disrupt biomolecules and cell organelles, leading to an inflammatory response and contributing to the development of health complications such as collagen deposition, aging, liver fibrosis, sepsis, ulcerative colitis, etc. Extracts of different plant species, phytochemicals, and Lactobacillus sp (probiotic) have been reported for their anti-oxidant potential. In this view, the researchers have gained significant interest in exploring the potential plants spp., their phytochemicals, and the potential of Lactobacillus sp. strains that exhibit anti-oxidant properties and health benefits. Thus, the current review focuses on comprehending the information related to the formation of H2O2, the factors influencing it, and their pathophysiology imposed on human health. Moreover, this review also discussed the anti-oxidant potential and role of different extract of plants, Lactobacillus sp. and their fermented products in curbing H2O2‑induced oxidative stress in both in-vitro and in-vivo models via boosting the anti-oxidative activity, inhibiting of important enzyme release and downregulation of cytochrome c, cleaved caspases-3, − 8, and − 9 expression. In particular, this knowledge will assist R&D sections in biopharmaceutical and food industries in developing herbal medicine and probiotics-based or derived food products that can effectively alleviate oxidative stress issues induced by H2O2 generation.

Original languageEnglish
Article number115022
JournalBiomedicine and Pharmacotherapy
StatePublished - Sep 2023
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2023 The Authors


The authors would like to thank the UHK PrF Excellence project 2208/2023-2024 , MH CZ - DRO ( UHHK, 00179906 ), King Saud University Researchers Supporting Project Number ( RSP2023R35 ) and by Scientific Grant Agency (VEGA Project 1/0482/20 ).

FundersFunder number
Univerzita Hradec Králové2208/2023-2024, 00179906
King Saud UniversityRSP2023R35
Vedecká Grantová Agentúra MŠVVaŠ SR a SAV1/0482/20


    • Anti-oxidant
    • Human health
    • Hydrogen peroxide
    • Oxidative stress
    • Plant phytoconstituents
    • Probiotics


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