TY - JOUR
T1 - Anti-alpha-actinin antibodies
T2 - A new marker of lupus nephritis
AU - Renaudineau, Yves
AU - Deocharan, Bisram
AU - Jousse, Sandrine
AU - Renaudineau, Eric
AU - Putterman, Chaim
AU - Youinou, Pierre
PY - 2007/8
Y1 - 2007/8
N2 - The exact role of anti-ds (double stranded) DNA antibodies in the pathogenesis of kidney injury in lupus nephritis remains a focus of continuing investigation. One theory explaining the pathogenicity of anti-dsDNA antibodies in lupus nephritis is direct cross-reactivity with renal antigens. Several years ago, α-actinin was identified as a major cross-reactive target for pathogenic anti-dsDNA antibodies in murine SLE. Indeed, binding of a nephritogenic murine anti-dsDNA antibody was stronger to the α-actinin derived from a lupus prone mouse mesangial cell line as compared to α-actinin in a non-autoimmune mouse mesangial cell line. Furthermore, we recently showed that immunization of non-autoimmune mice with α-actinin induces anti-chromatin antibodies, glomerular IgG deposition and proteinuria. In humans, anti-α-actinin autoantibodies (Ab) were associated with anti-dsDNA Ab in SLE. In those patients, anti-α-actinin rather than anti-dsDNA Ab were significantly associated with glomerulonephritis and disease activity. The anti-α-actinin reactivity was associated with high avidity anti-dsDNA Ab. Moreover, the anti-α-actinin response was related to the actin-binding site of α-actinin. Taken together, these studies indicate that detection of anti-α-actinin Ab, in association with anti-dsDNA Ab, may constitute a new marker in lupus nephritis.
AB - The exact role of anti-ds (double stranded) DNA antibodies in the pathogenesis of kidney injury in lupus nephritis remains a focus of continuing investigation. One theory explaining the pathogenicity of anti-dsDNA antibodies in lupus nephritis is direct cross-reactivity with renal antigens. Several years ago, α-actinin was identified as a major cross-reactive target for pathogenic anti-dsDNA antibodies in murine SLE. Indeed, binding of a nephritogenic murine anti-dsDNA antibody was stronger to the α-actinin derived from a lupus prone mouse mesangial cell line as compared to α-actinin in a non-autoimmune mouse mesangial cell line. Furthermore, we recently showed that immunization of non-autoimmune mice with α-actinin induces anti-chromatin antibodies, glomerular IgG deposition and proteinuria. In humans, anti-α-actinin autoantibodies (Ab) were associated with anti-dsDNA Ab in SLE. In those patients, anti-α-actinin rather than anti-dsDNA Ab were significantly associated with glomerulonephritis and disease activity. The anti-α-actinin reactivity was associated with high avidity anti-dsDNA Ab. Moreover, the anti-α-actinin response was related to the actin-binding site of α-actinin. Taken together, these studies indicate that detection of anti-α-actinin Ab, in association with anti-dsDNA Ab, may constitute a new marker in lupus nephritis.
KW - Anti-DNA
KW - Anti-α-actinin
KW - Autoantibodies
KW - Glomerulonephritis
KW - Systemic lupus erythematosus
UR - http://www.scopus.com/inward/record.url?scp=34447509652&partnerID=8YFLogxK
U2 - 10.1016/j.autrev.2007.02.001
DO - 10.1016/j.autrev.2007.02.001
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C2 - 17643934
AN - SCOPUS:34447509652
SN - 1568-9972
VL - 6
SP - 464
EP - 468
JO - Autoimmunity Reviews
JF - Autoimmunity Reviews
IS - 7
ER -