Ancient goat genomes reveal mosaic domestication in the Fertile Crescent

Kevin G. Daly; Pierpaolo Maisano Delser; Victoria E. Mullin; Amelie Scheu; Valeria Mattiangeli; Matthew D. Teasdale; Andrew J. Hare; Joachim Burger; Marta Pereira Verdugo; Matthew J. Collins; Ron Kehati; Cevdet Merih Erek; Guy Bar-Oz; François Pompanon; Tristan Cumer; Canan Çakırlar; Azadeh Fatemeh Mohaseb; Delphine Decruyenaere; Hossein Davoudi; Özlem Çevik; Gary Rollefson; Jean Denis Vigne; Roya Khazaeli; Homa Fathi; Sanaz Beizaee Doost; Roghayeh Rahimi Sorkhani; Ali Akbar Vahdati; Eberhard W. Sauer; Hossein Azizi Kharanaghi; Sepideh Maziar; Boris Gasparian; Ron Pinhasi; Louise Martin; David Orton; Benjamin S. Arbuckle; Norbert Benecke; Andrea Manica; Liora Kolska Horwitz; Marjan Mashkour; Daniel G. Bradley

doi:10.1126/science.aas9411

Ancient goat genomes reveal mosaic domestication in the Fertile Crescent

Kevin G. Daly
, Pierpaolo Maisano Delser
, Victoria E. Mullin
, Amelie Scheu
, Valeria Mattiangeli
, Matthew D. Teasdale
, Andrew J. Hare
, Joachim Burger
, Marta Pereira Verdugo
, Matthew J. Collins
, Ron Kehati
, Cevdet Merih Erek
, Guy Bar-Oz
, François Pompanon
, Tristan Cumer
, Canan Çakırlar
, Azadeh Fatemeh Mohaseb
, Delphine Decruyenaere
, Hossein Davoudi
, Özlem Çevik

Gary Rollefson, Jean Denis Vigne, Roya Khazaeli, Homa Fathi, Sanaz Beizaee Doost, Roghayeh Rahimi Sorkhani, Ali Akbar Vahdati, Eberhard W. Sauer, Hossein Azizi Kharanaghi, Sepideh Maziar, Boris Gasparian, Ron Pinhasi, Louise Martin, David Orton, Benjamin S. Arbuckle, Norbert Benecke, Andrea Manica, Liora Kolska Horwitz, Marjan Mashkour, Daniel G. Bradley

Trinity College Dublin
University of Cambridge
The Natural History Museum, London
Johannes Gutenberg University Mainz
University of York
University of Copenhagen
Hebrew University of Jerusalem
Gazi University
University of Haifa
Université Grenoble Alpes
University of Groningen
Sorbonne Université
University of Tehran
Tarbiat Modarres University
National Museum of Iran
Trakya University
Whitman College
Mazandaran University
Provincial Office of the Iranian Center for Cultural Heritage, Handicrafts and Tourism Organisation
University of Edinburgh
Goethe University Frankfurt
National Academy of Sciences of the Republic of Armenia
University of Vienna
University College London
University of North Carolina at Chapel Hill
German Archaeological Institute

Research output: Contribution to journal › Article › peer-review

175 Scopus citations

Abstract

Current genetic data are equivocal as to whether goat domestication occurred multiple times or was a singular process. We generated genomic data from 83 ancient goats (51 with genome-wide coverage) from Paleolithic to Medieval contexts throughout the Near East. Our findings demonstrate that multiple divergent ancient wild goat sources were domesticated in a dispersed process that resulted in genetically and geographically distinct Neolithic goat populations, echoing contemporaneous human divergence across the region. These early goat populations contributed differently to modern goats in Asia, Africa, and Europe. We also detect early selection for pigmentation, stature, reproduction, milking, and response to dietary change, providing 8000-year-old evidence for human agency in molding genome variation within a partner species.

Original language	English
Pages (from-to)	85-88
Number of pages	4
Journal	Science
Volume	361
Issue number	6397
DOIs	https://doi.org/10.1126/science.aas9411
State	Published - 6 Jul 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
2017 © The Authors.

Funding

Supported by ERC Investigator grant 295729-CodeX. Additional support from Science Foundation Ireland Award 12/ERC/B2227. P.M.D. was supported by the HERA Joint Research Programme “Uses of the Past” (CitiGen); and the European Union’s Horizon 2020 research and innovation program under grant agreement no. 649307. A.M. was supported by ERC Consolidator grant 647787-LocalAdaptation. M.D.T. was supported by the Marie Skłodowska-Curie Individual Fellowship SCRIBE H2020-MSCA-IF-2016 747424.

Funders	Funder number
Horizon 2020 Framework Programme	647787, 747424, 295729
H2020 European Research Council	295729-CodeX
University of International Business and Economics	H2020-MSCA-IF-2016 747424
Science Foundation Ireland	12/ERC/B2227

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Daly, K. G., Delser, P. M., Mullin, V. E., Scheu, A., Mattiangeli, V., Teasdale, M. D., Hare, A. J., Burger, J., Verdugo, M. P., Collins, M. J., Kehati, R., Erek, C. M., Bar-Oz, G., Pompanon, F., Cumer, T., Çakırlar, C., Mohaseb, A. F., Decruyenaere, D., Davoudi, H., ... Bradley, D. G. (2018). Ancient goat genomes reveal mosaic domestication in the Fertile Crescent. Science, 361(6397), 85-88. https://doi.org/10.1126/science.aas9411

@article{615387a1bf0e4ff49329b9011c524cc9,

title = "Ancient goat genomes reveal mosaic domestication in the Fertile Crescent",

abstract = "Current genetic data are equivocal as to whether goat domestication occurred multiple times or was a singular process. We generated genomic data from 83 ancient goats (51 with genome-wide coverage) from Paleolithic to Medieval contexts throughout the Near East. Our findings demonstrate that multiple divergent ancient wild goat sources were domesticated in a dispersed process that resulted in genetically and geographically distinct Neolithic goat populations, echoing contemporaneous human divergence across the region. These early goat populations contributed differently to modern goats in Asia, Africa, and Europe. We also detect early selection for pigmentation, stature, reproduction, milking, and response to dietary change, providing 8000-year-old evidence for human agency in molding genome variation within a partner species.",

author = "Daly, \{Kevin G.\} and Delser, \{Pierpaolo Maisano\} and Mullin, \{Victoria E.\} and Amelie Scheu and Valeria Mattiangeli and Teasdale, \{Matthew D.\} and Hare, \{Andrew J.\} and Joachim Burger and Verdugo, \{Marta Pereira\} and Collins, \{Matthew J.\} and Ron Kehati and Erek, \{Cevdet Merih\} and Guy Bar-Oz and Fran{\c c}ois Pompanon and Tristan Cumer and Canan {\c C}akırlar and Mohaseb, \{Azadeh Fatemeh\} and Delphine Decruyenaere and Hossein Davoudi and {\"O}zlem {\c C}evik and Gary Rollefson and Vigne, \{Jean Denis\} and Roya Khazaeli and Homa Fathi and Doost, \{Sanaz Beizaee\} and Sorkhani, \{Roghayeh Rahimi\} and Vahdati, \{Ali Akbar\} and Sauer, \{Eberhard W.\} and Kharanaghi, \{Hossein Azizi\} and Sepideh Maziar and Boris Gasparian and Ron Pinhasi and Louise Martin and David Orton and Arbuckle, \{Benjamin S.\} and Norbert Benecke and Andrea Manica and Horwitz, \{Liora Kolska\} and Marjan Mashkour and Bradley, \{Daniel G.\}",

note = "Publisher Copyright: 2017 {\textcopyright} The Authors.",

year = "2018",

month = jul,

day = "6",

doi = "10.1126/science.aas9411",

language = "אנגלית",

volume = "361",

pages = "85--88",

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Daly, KG, Delser, PM, Mullin, VE, Scheu, A, Mattiangeli, V, Teasdale, MD, Hare, AJ, Burger, J, Verdugo, MP, Collins, MJ, Kehati, R, Erek, CM, Bar-Oz, G, Pompanon, F, Cumer, T, Çakırlar, C, Mohaseb, AF, Decruyenaere, D, Davoudi, H, Çevik, Ö, Rollefson, G, Vigne, JD, Khazaeli, R, Fathi, H, Doost, SB, Sorkhani, RR, Vahdati, AA, Sauer, EW, Kharanaghi, HA, Maziar, S, Gasparian, B, Pinhasi, R, Martin, L, Orton, D, Arbuckle, BS, Benecke, N, Manica, A, Horwitz, LK, Mashkour, M & Bradley, DG 2018, 'Ancient goat genomes reveal mosaic domestication in the Fertile Crescent', Science, vol. 361, no. 6397, pp. 85-88. https://doi.org/10.1126/science.aas9411

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T1 - Ancient goat genomes reveal mosaic domestication in the Fertile Crescent

AU - Daly, Kevin G.

AU - Delser, Pierpaolo Maisano

AU - Mullin, Victoria E.

AU - Scheu, Amelie

AU - Mattiangeli, Valeria

AU - Teasdale, Matthew D.

AU - Hare, Andrew J.

AU - Burger, Joachim

AU - Verdugo, Marta Pereira

AU - Collins, Matthew J.

AU - Kehati, Ron

AU - Erek, Cevdet Merih

AU - Bar-Oz, Guy

AU - Pompanon, François

AU - Cumer, Tristan

AU - Çakırlar, Canan

AU - Mohaseb, Azadeh Fatemeh

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AU - Davoudi, Hossein

AU - Çevik, Özlem

AU - Rollefson, Gary

AU - Vigne, Jean Denis

AU - Khazaeli, Roya

AU - Fathi, Homa

AU - Doost, Sanaz Beizaee

AU - Sorkhani, Roghayeh Rahimi

AU - Vahdati, Ali Akbar

AU - Sauer, Eberhard W.

AU - Kharanaghi, Hossein Azizi

AU - Maziar, Sepideh

AU - Gasparian, Boris

AU - Pinhasi, Ron

AU - Martin, Louise

AU - Orton, David

AU - Arbuckle, Benjamin S.

AU - Benecke, Norbert

AU - Manica, Andrea

AU - Horwitz, Liora Kolska

AU - Mashkour, Marjan

AU - Bradley, Daniel G.

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Ancient goat genomes reveal mosaic domestication in the Fertile Crescent

Abstract

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