Ancient cattle genomics, origins, and rapid turnover in the Fertile Crescent

Marta Pereira Verdugo; Victoria E. Mullin; Amelie Scheu; Valeria Mattiangeli; Kevin G. Daly; Pierpaolo Maisano Delser; Andrew J. Hare; Joachim Burger; Matthew J. Collins; Ron Kehati; Paula Hesse; Deirdre Fulton; Eberhard W. Sauer; Fatemeh A. Mohaseb; Hossein Davoudi; Roya Khazaeli; Johanna Lhuillier; Claude Rapin; Saeed Ebrahimi; Mutalib Khasanov; S. M. Farhad Vahidi; David E. MacHugh; Okan Ertuğrul; Chaido Koukouli-Chrysanthaki; Adamantios Sampson; George Kazantzis; Ioannis Kontopoulos; Jelena Bulatovic; Ivana Stojanović; Abdesalam Mikdad; Norbert Benecke; Jörg Linstädter; Mikhail Sablin; Robin Bendrey; Lionel Gourichon; Benjamin S. Arbuckle; Marjan Mashkour; David Orton; Liora Kolska Horwitz; Matthew D. Teasdale; Daniel G. Bradley

doi:10.1126/science.aav1002

Ancient cattle genomics, origins, and rapid turnover in the Fertile Crescent

Marta Pereira Verdugo, Victoria E. Mullin, Amelie Scheu, Valeria Mattiangeli, Kevin G. Daly, Pierpaolo Maisano Delser, Andrew J. Hare, Joachim Burger, Matthew J. Collins, Ron Kehati, Paula Hesse, Deirdre Fulton, Eberhard W. Sauer, Fatemeh A. Mohaseb, Hossein Davoudi, Roya Khazaeli, Johanna Lhuillier, Claude Rapin, Saeed Ebrahimi, Mutalib KhasanovS. M. Farhad Vahidi, David E. MacHugh, Okan Ertuğrul, Chaido Koukouli-Chrysanthaki, Adamantios Sampson, George Kazantzis, Ioannis Kontopoulos, Jelena Bulatovic, Ivana Stojanović, Abdesalam Mikdad, Norbert Benecke, Jörg Linstädter, Mikhail Sablin, Robin Bendrey, Lionel Gourichon, Benjamin S. Arbuckle, Marjan Mashkour, David Orton, Liora Kolska Horwitz, Matthew D. Teasdale, Daniel G. Bradley

Research output: Contribution to journal › Article › peer-review

131 Scopus citations

Abstract

Genome-wide analysis of 67 ancient Near Eastern cattle, Bos taurus, remains reveals regional variation that has since been obscured by admixture in modern populations. Comparisons of genomes of early domestic cattle to their aurochs progenitors identify diverse origins with separate introgressions of wild stock. A later region-wide Bronze Age shift indicates rapid and widespread introgression of zebu, Bos indicus, from the Indus Valley. This process was likely stimulated at the onset of the current geological age, ~4.2 thousand years ago, by a widespread multicentury drought. In contrast to genome-wide admixture, mitochondrial DNA stasis supports that this introgression was male-driven, suggesting that selection of arid-adapted zebu bulls enhanced herd survival. This human-mediated migration of zebu-derived genetics has continued through millennia, altering tropical herding on each continent.

Original language	English
Pages (from-to)	173-176
Number of pages	4
Journal	Science
Volume	365
Issue number	6449
DOIs	https://doi.org/10.1126/science.aav1002
State	Published - 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019 American Association for the Advancement of Science. All rights reserved.

Funding

Supported by ERC Investigator grant 295729-CodeX. Additional support from Science Foundation Ireland Award 12/ERC/B2227, Trinseq and the SFI/HEA Irish Centre for High-End Computing (ICHEC). M.D.T. was partially supported by the Marie Skłodowska-Curie Individual Fellowship H2020-MSCA-IF-2016 747424 (SCRIBE). V.E.M. was partially supported by the NERC Grant NE/P012574/1. M.J.C. acknowledges support from DNRF128. P.M.D. was supported by the HERA Joint Research Programme “Uses of the Past” (CitiGen) and the European Union’s Horizon 2020 research and innovation program (649307).

Funders	Funder number
Horizon 2020 Framework Programme
H2020 Marie Skłodowska-Curie Actions	H2020-MSCA-IF-2016 747424
Seventh Framework Programme	649307, 747424, 295729
Natural Environment Research Council	NE/P012574/1, DNRF128
Science Foundation Ireland	12/ERC/B2227
Irish Centre for High-End Computing

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10.1126/science.aav1002

Cite this

Verdugo, M. P., Mullin, V. E., Scheu, A., Mattiangeli, V., Daly, K. G., Delser, P. M., Hare, A. J., Burger, J., Collins, M. J., Kehati, R., Hesse, P., Fulton, D., Sauer, E. W., Mohaseb, F. A., Davoudi, H., Khazaeli, R., Lhuillier, J., Rapin, C., Ebrahimi, S., ... Bradley, D. G. (2019). Ancient cattle genomics, origins, and rapid turnover in the Fertile Crescent. Science, 365(6449), 173-176. https://doi.org/10.1126/science.aav1002

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title = "Ancient cattle genomics, origins, and rapid turnover in the Fertile Crescent",

abstract = "Genome-wide analysis of 67 ancient Near Eastern cattle, Bos taurus, remains reveals regional variation that has since been obscured by admixture in modern populations. Comparisons of genomes of early domestic cattle to their aurochs progenitors identify diverse origins with separate introgressions of wild stock. A later region-wide Bronze Age shift indicates rapid and widespread introgression of zebu, Bos indicus, from the Indus Valley. This process was likely stimulated at the onset of the current geological age, ~4.2 thousand years ago, by a widespread multicentury drought. In contrast to genome-wide admixture, mitochondrial DNA stasis supports that this introgression was male-driven, suggesting that selection of arid-adapted zebu bulls enhanced herd survival. This human-mediated migration of zebu-derived genetics has continued through millennia, altering tropical herding on each continent.",

author = "Verdugo, {Marta Pereira} and Mullin, {Victoria E.} and Amelie Scheu and Valeria Mattiangeli and Daly, {Kevin G.} and Delser, {Pierpaolo Maisano} and Hare, {Andrew J.} and Joachim Burger and Collins, {Matthew J.} and Ron Kehati and Paula Hesse and Deirdre Fulton and Sauer, {Eberhard W.} and Mohaseb, {Fatemeh A.} and Hossein Davoudi and Roya Khazaeli and Johanna Lhuillier and Claude Rapin and Saeed Ebrahimi and Mutalib Khasanov and {Farhad Vahidi}, {S. M.} and MacHugh, {David E.} and Okan Ertuğrul and Chaido Koukouli-Chrysanthaki and Adamantios Sampson and George Kazantzis and Ioannis Kontopoulos and Jelena Bulatovic and Ivana Stojanovi{\'c} and Abdesalam Mikdad and Norbert Benecke and J{\"o}rg Linst{\"a}dter and Mikhail Sablin and Robin Bendrey and Lionel Gourichon and Arbuckle, {Benjamin S.} and Marjan Mashkour and David Orton and Horwitz, {Liora Kolska} and Teasdale, {Matthew D.} and Bradley, {Daniel G.}",

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doi = "10.1126/science.aav1002",

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volume = "365",

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Verdugo, MP, Mullin, VE, Scheu, A, Mattiangeli, V, Daly, KG, Delser, PM, Hare, AJ, Burger, J, Collins, MJ, Kehati, R, Hesse, P, Fulton, D, Sauer, EW, Mohaseb, FA, Davoudi, H, Khazaeli, R, Lhuillier, J, Rapin, C, Ebrahimi, S, Khasanov, M, Farhad Vahidi, SM, MacHugh, DE, Ertuğrul, O, Koukouli-Chrysanthaki, C, Sampson, A, Kazantzis, G, Kontopoulos, I, Bulatovic, J, Stojanović, I, Mikdad, A, Benecke, N, Linstädter, J, Sablin, M, Bendrey, R, Gourichon, L, Arbuckle, BS, Mashkour, M, Orton, D, Horwitz, LK, Teasdale, MD & Bradley, DG 2019, 'Ancient cattle genomics, origins, and rapid turnover in the Fertile Crescent', Science, vol. 365, no. 6449, pp. 173-176. https://doi.org/10.1126/science.aav1002

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AU - Verdugo, Marta Pereira

AU - Mullin, Victoria E.

AU - Scheu, Amelie

AU - Mattiangeli, Valeria

AU - Daly, Kevin G.

AU - Delser, Pierpaolo Maisano

AU - Hare, Andrew J.

AU - Burger, Joachim

AU - Collins, Matthew J.

AU - Kehati, Ron

AU - Hesse, Paula

AU - Fulton, Deirdre

AU - Sauer, Eberhard W.

AU - Mohaseb, Fatemeh A.

AU - Davoudi, Hossein

AU - Khazaeli, Roya

AU - Lhuillier, Johanna

AU - Rapin, Claude

AU - Ebrahimi, Saeed

AU - Khasanov, Mutalib

AU - Farhad Vahidi, S. M.

AU - MacHugh, David E.

AU - Ertuğrul, Okan

AU - Koukouli-Chrysanthaki, Chaido

AU - Sampson, Adamantios

AU - Kazantzis, George

AU - Kontopoulos, Ioannis

AU - Bulatovic, Jelena

AU - Stojanović, Ivana

AU - Mikdad, Abdesalam

AU - Benecke, Norbert

AU - Linstädter, Jörg

AU - Sablin, Mikhail

AU - Bendrey, Robin

AU - Gourichon, Lionel

AU - Arbuckle, Benjamin S.

AU - Mashkour, Marjan

AU - Orton, David

AU - Horwitz, Liora Kolska

AU - Teasdale, Matthew D.

AU - Bradley, Daniel G.

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Ancient cattle genomics, origins, and rapid turnover in the Fertile Crescent

Abstract

Bibliographical note

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