TY - JOUR
T1 - Analytical study of the effect of recombination on evolution via DNA shuffling
AU - Peng, Weiqun
AU - Levine, Herbert
AU - Hwa, Terence
AU - Kessler, David A.
PY - 2004/5
Y1 - 2004/5
N2 - DNA shuffling is an evolutionary protocol wherein cycles of selection, recombination, mutation, and amplification are employed to evolve proteins and DNA sequences. Experiments have shown its superiority to traditional protocols which do not employ recombination. Motivated by DNA shuffling, we investigate a multilocus evolutionary model that incorporates selection, recombination, and point mutations. Due to simplicity of the model, for the case of an infinite population we can obtain a full analytical treatment of both its dynamical and equilibrium properties, and study the benefit of recombination explicitly and quantitatively. We also briefly discuss finite-population size corrections.
AB - DNA shuffling is an evolutionary protocol wherein cycles of selection, recombination, mutation, and amplification are employed to evolve proteins and DNA sequences. Experiments have shown its superiority to traditional protocols which do not employ recombination. Motivated by DNA shuffling, we investigate a multilocus evolutionary model that incorporates selection, recombination, and point mutations. Due to simplicity of the model, for the case of an infinite population we can obtain a full analytical treatment of both its dynamical and equilibrium properties, and study the benefit of recombination explicitly and quantitatively. We also briefly discuss finite-population size corrections.
UR - https://www.scopus.com/pages/publications/85036318892
U2 - 10.1103/PhysRevE.69.051911
DO - 10.1103/PhysRevE.69.051911
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C2 - 15244851
AN - SCOPUS:85036318892
SN - 2470-0045
VL - 69
SP - 15
JO - Physical Review E
JF - Physical Review E
IS - 5
ER -