Analysis of fatty acid anhydrides and polyanhydrides

Neeraj Kumar; Mahesh Krishnan; Tony Azzam; Amir Magora; Majeti N.V. Ravikumar; Douglas R. Flanagan; Abraham J. Domb

doi:10.1016/s0003-2670(02)00468-3

Analysis of fatty acid anhydrides and polyanhydrides

Neeraj Kumar, Mahesh Krishnan, Tony Azzam, Amir Magora, Majeti N.V. Ravikumar, Douglas R. Flanagan, Abraham J. Domb

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Acid anhydrides are considered as important reagents in organic and peptide synthesis and in recent years for the formation of prodrugs and biomaterials for controlled release of drugs. This article highlights the analysis of mixed anhydrides and polyanhydrides synthesized by various methods. Analytical methods including HPLC, GLC, ¹H NMR and IR spectroscopy are described for the determination of anhydride hydrolysis and amidation.

Original language	English
Pages (from-to)	257-272
Number of pages	16
Journal	Analytica Chimica Acta
Volume	465
Issue number	1-2
DOIs	https://doi.org/10.1016/s0003-2670(02)00468-3
State	Published - 16 Aug 2002
Externally published	Yes

Bibliographical note

Funding Information:
Neeraj Kumar is a Lady Davis Fellow and thankful to Lady Davis Trust for financial assistance.

Funding

Neeraj Kumar is a Lady Davis Fellow and thankful to Lady Davis Trust for financial assistance.

Funders	Funder number
Lady Davis Trust

Keywords

Anhydride
Anhydride analysis
Hydrolytic degradation
Mixed anhydride
Prodrug

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10.1016/s0003-2670(02)00468-3

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title = "Analysis of fatty acid anhydrides and polyanhydrides",

abstract = "Acid anhydrides are considered as important reagents in organic and peptide synthesis and in recent years for the formation of prodrugs and biomaterials for controlled release of drugs. This article highlights the analysis of mixed anhydrides and polyanhydrides synthesized by various methods. Analytical methods including HPLC, GLC, 1H NMR and IR spectroscopy are described for the determination of anhydride hydrolysis and amidation.",

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AU - Krishnan, Mahesh

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AU - Magora, Amir

AU - Ravikumar, Majeti N.V.

AU - Flanagan, Douglas R.

AU - Domb, Abraham J.

N1 - Funding Information: Neeraj Kumar is a Lady Davis Fellow and thankful to Lady Davis Trust for financial assistance.

PY - 2002/8/16

Y1 - 2002/8/16

N2 - Acid anhydrides are considered as important reagents in organic and peptide synthesis and in recent years for the formation of prodrugs and biomaterials for controlled release of drugs. This article highlights the analysis of mixed anhydrides and polyanhydrides synthesized by various methods. Analytical methods including HPLC, GLC, 1H NMR and IR spectroscopy are described for the determination of anhydride hydrolysis and amidation.

AB - Acid anhydrides are considered as important reagents in organic and peptide synthesis and in recent years for the formation of prodrugs and biomaterials for controlled release of drugs. This article highlights the analysis of mixed anhydrides and polyanhydrides synthesized by various methods. Analytical methods including HPLC, GLC, 1H NMR and IR spectroscopy are described for the determination of anhydride hydrolysis and amidation.

KW - Anhydride

KW - Anhydride analysis

KW - Hydrolytic degradation

KW - Mixed anhydride

KW - Prodrug

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Analysis of fatty acid anhydrides and polyanhydrides

Abstract

Bibliographical note

Funding

Keywords

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