An update on treatment options for pancreatic adenocarcinoma

Aurélien Lambert, Lilian Schwarz, Ivan Borbath, Aline Henry, Jean Luc Van Laethem, David Malka, Michel Ducreux, Thierry Conroy

Research output: Contribution to journalReview articlepeer-review

151 Scopus citations

Abstract

Pancreatic cancer is one of the most lethal solid organ tumors. Due to the rising incidence, late diagnosis, and limited treatment options, it is expected to be the second leading cause of cancer deaths in high income countries in the next decade. The multidisciplinary treatment of this disease depends on the stage of cancer at diagnosis (resectable, borderline, locally advanced, and metastatic disease), and combines surgery, chemotherapy, chemoradiotherapy, and supportive care. The landscape of multidisciplinary pancreatic cancer treatment is changing rapidly, especially in locally advanced disease, and the number of treatment options in metastatic disease, including personalized medicine, innovative targets, immunotherapy, therapeutic vaccines, adoptive T-cell transfer, or stemness inhibitors, will probably expand in the near future. This review summarizes the current literature and provides an overview of how new therapies or new therapeutic strategies (neoadjuvant therapies, conversion surgery) will guide multidisciplinary disease management, future clinical trials, and, hopefully, will increase overall survival.

Original languageEnglish
JournalTherapeutic Advances in Medical Oncology
Volume11
DOIs
StatePublished - 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
© The Author(s), 2019.

Funding

The authors wrote the paper and agreed on the content. The manuscript has been revised for English by an independent scientific language editing service, Angloscribe, and the Institut de Cancérologie de Lorraine paid for this editing assistance. The author(s) received no financial support for the research, authorship, and publication of this article.

FundersFunder number
Institut de Cancérologie de Lorraine

    Keywords

    • FOLFIRINOX
    • adjuvant chemotherapy
    • borderline pancreatic cancer
    • guidelines
    • pancreatic cancer
    • supportive care
    • surgery

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