An overview of biomedical applications for gold nanoparticles against lung cancer

Varsha Kumari, Sukriti Vishwas, Rajesh Kumar, Violina Kakoty, Rubiya Khursheed, Molakpogu Ravindra Babu, Vancha Harish, Neeraj Mittal, Pankaj Kumar Singh, Nahed S. Alharthi, Mohammed Ageeli Hakami, Faris F. Aba Alkhayl, Gaurav Gupta, Gabriele De Rubis, Keshav Raj Paudel, Manisha Singh, Milad Zandi, Brian G. Oliver, Kamal Dua, Sachin Kumar Singh

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Lung cancer (LC) is the commonest class of cancer worldwide and is the reason for more deaths than any other type. Treatment of LC using conventional therapy has some limitations such as poor bioavailability and non-site release of drug causing various side effects. However, the use of nanotechnology makes it possible to offer efficacious treatment of LC by offering nanometer sized formulation that helps in better penetration of drug inside tumor cells and site specific drug release. Among various nanoparticles, gold nanoparticles (GNPs) has found unique and important application in the biomedical application of nanoparticles in various diseases, especially cancer. Owing to their high biocompatibility and stability against oxidation in vivo, tunable nano size, ease of functionalization with chemotherapeutic agents, capacity to enhance bioavailability and site specificity of entrapped drug, capacity to interact with visible light, make GNPs as special carrier for biomedical application in LC. GNPs can absorb infrared radiation and have optical qualities as well. In the present review, various aspects of LC and theranostic role of GNPs are comprehensively covered. These include prevalence, classification, economic burden, pathophysiology as well as commonly available therapies of LC. This was followed by advantages, synthesis, biomedical application of GNPs in treating LC as well as their fate in the body. Overall, the uniqueness of review relies on the fact that it covers all aspects of LC and all possibilities by which GNPs can offer their best role in management of LC.

Original languageEnglish
Article number104729
JournalJournal of Drug Delivery Science and Technology
Volume86
DOIs
StatePublished - Sep 2023
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2023 Elsevier B.V.

Funding

Kamal Dua is supported by a project grant from the Rebecca L Cooper Medical Research Foundation and the Maridulu Budyari Gumal Sydney Partnership for Health, Education, Research and Enterprise(SPHERE) RSEOH CAG Seed grant, fellowship and extension grant; Faculty of Health MCR/ECR Mentorship Support Grant and UTS Global Strategic Partnerships Seed Funding Scheme. We are also thankful to Embase, Elsevier for providing support related to literature review.

FundersFunder number
Maridulu Budyari Gumal Sydney Partnership for Health, Education, Research and Enterprise
Rebecca L. Cooper Medical Research Foundation
University of Technology Sydney
Sydney Partnership for Health, Education, Research and Enterprise

    Keywords

    • Gold nanoparticles
    • Hyperthermal therapy
    • Immunosensors
    • Lung cancer
    • Surface plasmon resonance
    • Theranostic agents

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