An α-amino ketone to α-ketol transformation in the reduction of 16-oximino-17-ketosteroids

Alfred Hassner, A. W. Coulter

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The unusual conversion of 16-oximino-5-androsten-3β-ol-17-one (I) to 5-androsten-3β, 17β-diol-16-one (III) with zinc acetic in acid is shown to proceed via the 16-amino-17-ketosteroid intermediate II. Deuterium labelling experiments were used to elucidate the reaction path.

Original languageEnglish
Pages (from-to)281-290
Number of pages10
JournalSteroids
Volume4
Issue number3
DOIs
StatePublished - Sep 1964
Externally publishedYes

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