Alternating Poly(ester-anhydride) by Insertion Polycondensation

Moran Haim-Zada, Arijit Basu, Tal Hagigit, Ron Schlinger, Michael Grishko, Alexander Kraminsky, Ezra Hanuka, Abraham J. Domb

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


We report on a synthetic method where polyanhydride is used as starting material and the ester monomers are inserted through complete esterification, leading to an alternating ester-anhydride copolymer. The molar ratio of ricinoleic acid (RA) and sebacic acid (SA) was optimized until polysebacic acid is completely converted to carboxylic acid-terminated RA-SA and RA-SA-RA ester-dicarboxylic acids. These dimers and trimers were activated with acetic anhydride, polymerized under heat and vacuum to yield alternating RA-SA copolymer. The resulting alternating poly(ester-anhydride) have the RA at regular intervals. The regular occurrences of RA side chains prevent anhydride interchange, enhancing hydrolytic stability, which allows storage of the polymer at room temperature.

Original languageEnglish
Pages (from-to)2253-2259
Number of pages7
Issue number6
StatePublished - 13 Jun 2016
Externally publishedYes

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© 2016 American Chemical Society.


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