Altered brain activation during response inhibition in obstructive sleep apnea

Liat Ayalon; Sonia Ancoli-Israel; Sean Pa Drummond

doi:10.1111/j.1365-2869.2008.00707.x

Altered brain activation during response inhibition in obstructive sleep apnea

Liat Ayalon, Sonia Ancoli-Israel, Sean Pa Drummond

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

This study examined response inhibition during a Go-NoGo task in individuals with obstructive sleep apnea (OSA). Fourteen OSA patients and 14 controls were studied with functional magnetic resonance imaging. Compared to controls, the OSA group showed more false positives (error of commission) during the NoGo trials with decreased brain activation in the left postcentral gyrus, cingulate gyrus and inferior parietal lobe, as well as right insula and putamen. This is consistent with previous findings of impaired performance and decreased brain activation in OSA patients during a working memory task, suggesting that compromised brain function in response to cognitive challenges may underlie some of the cognitive deficits seen in patients with OSA.

Original language	English
Pages (from-to)	204-208
Number of pages	5
Journal	Journal of Sleep Research
Volume	18
Issue number	2
DOIs	https://doi.org/10.1111/j.1365-2869.2008.00707.x
State	Published - Jun 2009
Externally published	Yes

Funding

Funders	Funder number
National Institute of Mental Health	T32MH018399
National Institute on Aging	R01AG008415
National Center for Research Resources	M01RR000827

Keywords

Brain activation
Functional magnetic resonance imaging
Obstructive sleep apnea
Response inhibition
Sleep

Access to Document

10.1111/j.1365-2869.2008.00707.x

Cite this

@article{a931d51d0bd2481e900145eaa77b1f84,

title = "Altered brain activation during response inhibition in obstructive sleep apnea",

abstract = "This study examined response inhibition during a Go-NoGo task in individuals with obstructive sleep apnea (OSA). Fourteen OSA patients and 14 controls were studied with functional magnetic resonance imaging. Compared to controls, the OSA group showed more false positives (error of commission) during the NoGo trials with decreased brain activation in the left postcentral gyrus, cingulate gyrus and inferior parietal lobe, as well as right insula and putamen. This is consistent with previous findings of impaired performance and decreased brain activation in OSA patients during a working memory task, suggesting that compromised brain function in response to cognitive challenges may underlie some of the cognitive deficits seen in patients with OSA.",

keywords = "Brain activation, Functional magnetic resonance imaging, Obstructive sleep apnea, Response inhibition, Sleep",

author = "Liat Ayalon and Sonia Ancoli-Israel and Drummond, {Sean Pa}",

year = "2009",

month = jun,

doi = "10.1111/j.1365-2869.2008.00707.x",

language = "אנגלית",

volume = "18",

pages = "204--208",

journal = "Journal of Sleep Research",

issn = "0962-1105",

publisher = "John Wiley and Sons Inc.",

number = "2",

}

TY - JOUR

T1 - Altered brain activation during response inhibition in obstructive sleep apnea

AU - Ayalon, Liat

AU - Ancoli-Israel, Sonia

AU - Drummond, Sean Pa

PY - 2009/6

Y1 - 2009/6

N2 - This study examined response inhibition during a Go-NoGo task in individuals with obstructive sleep apnea (OSA). Fourteen OSA patients and 14 controls were studied with functional magnetic resonance imaging. Compared to controls, the OSA group showed more false positives (error of commission) during the NoGo trials with decreased brain activation in the left postcentral gyrus, cingulate gyrus and inferior parietal lobe, as well as right insula and putamen. This is consistent with previous findings of impaired performance and decreased brain activation in OSA patients during a working memory task, suggesting that compromised brain function in response to cognitive challenges may underlie some of the cognitive deficits seen in patients with OSA.

AB - This study examined response inhibition during a Go-NoGo task in individuals with obstructive sleep apnea (OSA). Fourteen OSA patients and 14 controls were studied with functional magnetic resonance imaging. Compared to controls, the OSA group showed more false positives (error of commission) during the NoGo trials with decreased brain activation in the left postcentral gyrus, cingulate gyrus and inferior parietal lobe, as well as right insula and putamen. This is consistent with previous findings of impaired performance and decreased brain activation in OSA patients during a working memory task, suggesting that compromised brain function in response to cognitive challenges may underlie some of the cognitive deficits seen in patients with OSA.

KW - Brain activation

KW - Functional magnetic resonance imaging

KW - Obstructive sleep apnea

KW - Response inhibition

KW - Sleep

UR - http://www.scopus.com/inward/record.url?scp=65749104595&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2869.2008.00707.x

DO - 10.1111/j.1365-2869.2008.00707.x

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 19302344

AN - SCOPUS:65749104595

SN - 0962-1105

VL - 18

SP - 204

EP - 208

JO - Journal of Sleep Research

JF - Journal of Sleep Research

IS - 2

ER -

Altered brain activation during response inhibition in obstructive sleep apnea

Abstract

Funding

Keywords

Access to Document

Other files and links

Fingerprint

Cite this