TY - JOUR
T1 - Alterations to task positive and task negative networks during executive functioning in Mild Cognitive Impairment
AU - Melrose, Rebecca J.
AU - Jimenez, Amy M.
AU - Riskin-Jones, Hannah
AU - Weissberger, Gali
AU - Veliz, Joseph
AU - Hasratian, Arpi S.
AU - Wilkins, Stacy
AU - Sultzer, David L.
N1 - Publisher Copyright:
© 2018
PY - 2018
Y1 - 2018
N2 - Poor executive functioning increases risk of decline in Mild Cognitive Impairment (MCI). Executive functioning can be conceptualized within the framework of working memory. While some components are responsible for maintaining representations in working memory, the central executive is involved in the manipulation of information and creation of new representations. We aimed to examine the neural correlates of these components of working memory using a maintenance working memory and visuospatial reasoning task. Twenty-five patients with amnestic MCI and 19 elderly controls (EC) completed functional MRI during reasoning and maintenance working memory tasks. In MCI, maintenance working memory was associated with hypoactivation of right frontoparietal regions and hyperactivation of left prefrontal cortex, coupled with attenuation of default mode network (DMN) relative to EC. During reasoning, MCI showed hypoactivation of parietal regions, coupled with attenuation of anterior DMN and increased deactivation of posterior DMN relative to EC. Comparing the reasoning task to the maintenance working memory task yields the central executive. In MCI, the central executive showed hypoactivation of right parietal lobe and increased deactivation of posterior DMN compared to EC. Consistent with prior work on executive functioning, MCI show different neural circuitry during visuospatial reasoning, including changes to both task positive frontoparietal regions, as well as to deactivation patterns within the DMN. Both hyperactivation of task positive networks and increased deactivation of DMN may be compensatory.
AB - Poor executive functioning increases risk of decline in Mild Cognitive Impairment (MCI). Executive functioning can be conceptualized within the framework of working memory. While some components are responsible for maintaining representations in working memory, the central executive is involved in the manipulation of information and creation of new representations. We aimed to examine the neural correlates of these components of working memory using a maintenance working memory and visuospatial reasoning task. Twenty-five patients with amnestic MCI and 19 elderly controls (EC) completed functional MRI during reasoning and maintenance working memory tasks. In MCI, maintenance working memory was associated with hypoactivation of right frontoparietal regions and hyperactivation of left prefrontal cortex, coupled with attenuation of default mode network (DMN) relative to EC. During reasoning, MCI showed hypoactivation of parietal regions, coupled with attenuation of anterior DMN and increased deactivation of posterior DMN relative to EC. Comparing the reasoning task to the maintenance working memory task yields the central executive. In MCI, the central executive showed hypoactivation of right parietal lobe and increased deactivation of posterior DMN compared to EC. Consistent with prior work on executive functioning, MCI show different neural circuitry during visuospatial reasoning, including changes to both task positive frontoparietal regions, as well as to deactivation patterns within the DMN. Both hyperactivation of task positive networks and increased deactivation of DMN may be compensatory.
KW - Default mode network
KW - Executive functioning
KW - Mild cognitive impairment
KW - Prefrontal cortex
KW - Working memory
UR - http://www.scopus.com/inward/record.url?scp=85048964406&partnerID=8YFLogxK
U2 - 10.1016/j.nicl.2018.06.014
DO - 10.1016/j.nicl.2018.06.014
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C2 - 30003034
AN - SCOPUS:85048964406
SN - 2213-1582
VL - 19
SP - 970
EP - 981
JO - NeuroImage: Clinical
JF - NeuroImage: Clinical
ER -