Alterations in purine nucleotide metabolism during muscle differentiation in vitro

Esther Zoref-Shani, Asher Shainberg, Oded Sperling

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Pathways of purine nucleotide metabolism affecting the availability of ATP in the muscle tissue were studied in differentiating rat muscle cultures. The rate of de novo purine nucleotide synthesis and of AMP deamination were found to increase markedly with cell differentiation, but the rate of IMP dephosphorylation was similarly low in both myoblasts and contracting fibers. The above differentiation-associated alterations in purine nucleotide metabolism conform with the greater need for ATP as a source of energy in the contracting myotubes.

Original languageEnglish
Pages (from-to)507-512
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number2
StatePublished - 31 Oct 1983


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