Alopecia Areata as a Proximal Risk Factor for the Development of Comorbid Depression: A Population-based Study

Dana Tzur Bitan; Daniella Berzin; Khalaf Kridin; Yaron Sela; Arnon Cohen

doi:10.2340/actadv.v102.1622

Alopecia Areata as a Proximal Risk Factor for the Development of Comorbid Depression: A Population-based Study

Dana Tzur Bitan, Daniella Berzin, Khalaf Kridin, Yaron Sela, Arnon Cohen

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Alopecia areata and depression tend to co-occur; however, their temporal association has not been comprehensively investigated. The aim of this study was to examine the temporal association between alopecia areata and depression. The study included only cases with a comorbid presentation of alopecia areata and depression (n = 1,936), extracted from the databases of the Clalit Health Services, Israel. Survival analyses were used to assess the cumulative probability of receiving alopecia areata as comorbid diagnosis in the years following depression, and vice versa, compared with the opposite trajectory. The results indicate that patients with alopecia areata had greater odds of subsequent depression within 2 years from alopecia areata diagnosis, and showed a steeper increase in cumulative probability of depression as time progressed (log-rank =336.38, p < 0.001), compared with the opposite trajectory. All patients with alopecia areata had comorbid depression within 10 years of alopecia areata, compared with 70% of depression patients receiving diagnoses of comorbid alopecia areata within the same time-frame.

Original language	English
Article number	adv00669
Journal	Acta Dermato-Venereologica
Volume	102
DOIs	https://doi.org/10.2340/actadv.v102.1622
State	Published - 14 Mar 2022
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2022, Medical Journals/Acta D-V. All rights reserved.

Funding

This study was supported by an unrestricted grant from Pfizer Pharmaceuticals Israel (grant number 55988381). Conflicts of interest. DTB received a research grant from Pfizer and from the American Psychological Foundation. AC received research grants from Janssen, Novartis, AbbVie, Janssen and Sa-nofi. He aslo served as a consultant, advisor, or speaker to AbbVie, Amgen, Boehringer Ingelheim, Dexcel pharma, Janssen, Kamedis, Lilly, Neopharm, Novartis, Perrigo, Pfizer, Rafa, Samsung Bioepis, Sanofi, Sirbal, and Taro.

Funders	Funder number
Pfizer Pharmaceuticals Israel	55988381
Pfizer
Novartis
Janssen Pharmaceuticals

Keywords

alopecia areata
comorbidity: temporal precedence
depression

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10.2340/actadv.v102.1622

Cite this

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abstract = "Alopecia areata and depression tend to co-occur; however, their temporal association has not been comprehensively investigated. The aim of this study was to examine the temporal association between alopecia areata and depression. The study included only cases with a comorbid presentation of alopecia areata and depression (n = 1,936), extracted from the databases of the Clalit Health Services, Israel. Survival analyses were used to assess the cumulative probability of receiving alopecia areata as comorbid diagnosis in the years following depression, and vice versa, compared with the opposite trajectory. The results indicate that patients with alopecia areata had greater odds of subsequent depression within 2 years from alopecia areata diagnosis, and showed a steeper increase in cumulative probability of depression as time progressed (log-rank =336.38, p < 0.001), compared with the opposite trajectory. All patients with alopecia areata had comorbid depression within 10 years of alopecia areata, compared with 70% of depression patients receiving diagnoses of comorbid alopecia areata within the same time-frame.",

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Alopecia Areata as a Proximal Risk Factor for the Development of Comorbid Depression: A Population-based Study

Abstract

Bibliographical note

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Keywords

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