Aging effects on cardiac and respiratory dynamics in healthy subjects across sleep stages

Aicko Y. Schumann, Ronny P. Bartsch, Thomas Penzel, Plamen Ch Ivanov, Jan W. Kantelhardt

Research output: Contribution to journalArticlepeer-review

98 Scopus citations

Abstract

Study Objectives: Respiratory and heart rate variability exhibit fractal scaling behavior on certain time scales. We studied the short-term and long-term correlation properties of heartbeat and breathing-interval data from disease-free subjects focusing on the age-dependent fractal organization. We also studied differences across sleep stages and night-time wake and investigated quasi-periodic variations associated with cardiac risk. Design: Full-night polysomnograms were recorded during 2 nights, including electrocardiogram and oronasal airflow. Setting: Data were collected in 7 laboratories in 5 European countries. Participants: 180 subjects without health complaints (85 males, 95 females) aged from 20 to 89 years. Interventions: None. Measurements and Results: Short-term correlations in heartbeat intervals measured by the detrended fluctuation analysis (DFA) exponent α1 show characteristic age dependence with a maximum around 50-60 years disregarding the dependence on sleep and wake states. Long-term correlations measured by α2 differ in NREM sleep when compared with REM sleep and wake, besides weak age dependence. Results for respiratory intervals are similar to those for α2 of heartbeat intervals. Deceleration capacity (DC) decreases with age; it is lower during REM and deep sleep (compared with light sleep and wake). Conclusion: The age dependence of α1 should be considered when using this value for diagnostic purposes in post-infarction patients. Pronounced long-term correlations (larger α2) for heartbeat and respiration during REM sleep and wake indicate an enhanced control of higher brain regions, which is absent during NREM sleep. Reduced DC possibly indicates an increased cardiovascular risk with aging and during REM and deep sleep.

Original languageEnglish
Pages (from-to)943-955
Number of pages13
JournalSleep
Volume33
Issue number7
DOIs
StatePublished - 1 Jul 2010
Externally publishedYes

Keywords

  • Aging
  • Cardiac risk
  • Deceleration capacity
  • Detrended fluctuation analysis
  • Heart rate variability
  • Phase rectified signal averaging
  • Respiration
  • Scaling
  • Sleep

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