@article{0c639c0f72ea46a983190a3476a2f894,
title = "Aggregation and disaggregation of senile plaques in Alzheimer disease",
abstract = "We quantitatively analyzed, using laser scanning confocal microscopy, the three-dimensional structure of individual senile plaques in Alzheimer disease. We carried nut the quantitative analysis using statistical methods to gain insights about the processes that govern Aβ peptide deposition. Our results show that plaques are complex porous structures with characteristic pore sizes. We interpret plaque morphology in the context of a new dynamical model based on competing aggregation and disaggregation processes in kinetic steady-state equilibrium with an additional diffusion process allowing Aβ deposits to diffuse over the surface of plaques.",
author = "L. Cruz and B. Urbanc and Buldyrev, {S. V.} and R. Christie and T. G{\'o}mez-Isla and S. Havlin and M. Mcnamara and Stanley, {H. E.} and Hyman, {B. T.}",
year = "1997",
month = jul,
day = "8",
doi = "10.1073/pnas.94.14.7612",
language = "אנגלית",
volume = "94",
pages = "7612--7616",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "14",
}