Aggregation and disaggregation of senile plaques in Alzheimer disease

L. Cruz, B. Urbanc, S. V. Buldyrev, R. Christie, T. Gómez-Isla, S. Havlin, M. Mcnamara, H. E. Stanley, B. T. Hyman

Research output: Contribution to journalArticlepeer-review

92 Scopus citations

Abstract

We quantitatively analyzed, using laser scanning confocal microscopy, the three-dimensional structure of individual senile plaques in Alzheimer disease. We carried nut the quantitative analysis using statistical methods to gain insights about the processes that govern Aβ peptide deposition. Our results show that plaques are complex porous structures with characteristic pore sizes. We interpret plaque morphology in the context of a new dynamical model based on competing aggregation and disaggregation processes in kinetic steady-state equilibrium with an additional diffusion process allowing Aβ deposits to diffuse over the surface of plaques.

Original languageEnglish
Pages (from-to)7612-7616
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume94
Issue number14
DOIs
StatePublished - 8 Jul 1997

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