Advances in understanding the molecular basis of the first steps in color vision

Lukas Hofmann; Krzysztof Palczewski

doi:10.1016/j.preteyeres.2015.07.004

Advances in understanding the molecular basis of the first steps in color vision

Lukas Hofmann, Krzysztof Palczewski

Case Western Reserve University

Research output: Contribution to journal › Review article › peer-review

37 Scopus citations

Abstract

Serving as one of our primary environmental inputs, vision is the most sophisticated sensory system in humans. Here, we present recent findings derived from energetics, genetics and physiology that provide a more advanced understanding of color perception in mammals. Energetics of cis-trans isomerization of 11-cis-retinal accounts for color perception in the narrow region of the electromagnetic spectrum and how human eyes can absorb light in the near infrared (IR) range. Structural homology models of visual pigments reveal complex interactions of the protein moieties with the light sensitive chromophore 11-cis-retinal and that certain color blinding mutations impair secondary structural elements of these G protein-coupled receptors (GPCRs). Finally, we identify unsolved critical aspects of color tuning that require future investigation.

Original language	English
Pages (from-to)	46-66
Number of pages	21
Journal	Progress in Retinal and Eye Research
Volume	49
DOIs	https://doi.org/10.1016/j.preteyeres.2015.07.004
State	Published - Nov 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Ltd.

Funding

We thank especially Drs. Leslie T. Webster, Jr., Maureen Neitz, Adam Smith and Massimo Olivucci for insightful comments on this manuscript. Additional comments from Drs. David T. Lodowski, Yoshikazu Imanishi, Paul S. Park, Johannes Von Lintig, John J. Mieyal, and members of the Palczewski laboratory were most helpful. This work was supported by funding from the National Institutes of Health EY009339 (KP), and Arnold and Mabel Beckman Foundation . L. H. is supported by the Swiss National Science Foundation Doc.Mobility fellowship ( P1SKP3_158634 ). K.P. is John H. Hord Professor of Pharmacology.

Funders	Funder number
National Institutes of Health
National Eye Institute	R01EY009339
Arnold and Mabel Beckman Foundation
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung	P1SKP3_158634

Keywords

Color blindness
Color vision
Cone photoreceptor(s)
Energetics
Retina
Spectral tuning
Vision
Visual pigments

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10.1016/j.preteyeres.2015.07.004

Cite this

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Advances in understanding the molecular basis of the first steps in color vision

Abstract

Bibliographical note

Funding

Keywords

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