Abstract
The study of DNA-protein interactions is gaining increased attention due to their importance in cellular processes. Only a well-functioning interaction guaranties that such a process can take place without errors. So far, only a small percentage of these interactions have been unraveled, partially due to their complexity but also due to the fact that there are only a few techniques that permit the study of these interactions. In this report we describe the development of a research tool based on tethered bead motion and Resonance Light Scattering (RLS) from gold beads. This method permits the study of DNA-protein interactions and the screening of proteins binding to a specific DNA sequence.
Original language | English |
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Article number | 60920C |
Journal | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
Volume | 6092 |
DOIs | |
State | Published - 2006 |
Externally published | Yes |
Event | Ultrasensitive and Single-Molecule Detection Technologies - San Jose, CA, United States Duration: 21 Jan 2006 → 24 Jan 2006 |
Keywords
- Molecular interactions
- Quantitative microscopy
- Resonance light scattering
- Single molecule detection