Adrenal desensitization following prolonged acth administration to normal subjects

Z. Kraiem, T. Rosenthal, R. Rotzak, B. Lunenfeld

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3 Scopus citations


The aim of this investigation was to determine whether the adrenal, having reached the refractory state with respect to aldosterone secretion as a result of prolonged ACTH exposure, would respond to the other major stimuli of the mineralocorticoid: angiotensin II and K. Twelve healthy male volunteers on a normal Na and K intake and ambulatory received ACTH (40 IU, i.m.) twice daily for 5 days followed by 2 days of angiotensin II (5-13ng/kg body wt/min for 60min) or oral K citrate (30 mEq/h × 3). A discordance in the aldosterone-stimulating and pressor responses of angiotensin II was unmasked with only the latter response being positive following ACTH-induced refractoriness. In contrast to angiotensin II, K could selectively enhance aldosterone secretion by overcoming the inhibition in secretion of the mineralocorticoid induced by prolonged ACTH exposure.

Original languageEnglish
Pages (from-to)469-472
Number of pages4
JournalJournal of Steroid Biochemistry
Issue numberC
StatePublished - Jan 1980
Externally publishedYes


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