Adhesive tablet effective for treating canker sores in humans

Boaz Mizrahi, Jacob Golenser, Joseph S. Wolnerman, Abraham J. Domb

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


A new mucoadhesive tablet, which releases natural active agents for pain reduction and rapid healing of canker sores, has been prepared and characterized. Adhesive tablets were prepared by compression molding of mixed powders of crosslinked polyacrylic acid and hydroxypropyl cellulose, absorbed with citrus oil and magnesium salt. The rate of tablet erosion and the rates of citrus oil and magnesium release were determined as well as the adhesiveness of the tablet using bovine gingival tissue and an Instron tensiometer. A clinical trial was conducted on 248 volunteers who had canker sores. Tablets adhere well to the mucosal tissue and gradually erode for 8 h releasing the citrus oil in a zero-order pattern whereas the magnesium is released during a period of 2 h. Both experimental and plain tablets were effective in reducing pain and decreasing healing time (p < 0.05) without adverse side effects. However, the tablets loaded with active agents were more effective.

Original languageEnglish
Pages (from-to)2927-2935
Number of pages9
JournalJournal of Pharmaceutical Sciences
Issue number12
StatePublished - Dec 2004
Externally publishedYes


  • Buccal
  • Controlled release
  • Mucosal delivery
  • Polymers


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