Adherence to guideline-directed medical treatments in heart failure. A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on Cardiovascular Pharmacotherapy

Gianluigi Savarese; Felix Lindberg; Antonio Cannata; Marianna Adamo; Giuseppe Ambrosio; Pietro Ameri; Markus S. Anker; Magnus Bäck; Antoni Bayes-Genis; Tuvia Ben Gal; Frieder Braunschweig; Ovidiu Chioncel; Emilia D'Elia; Hassan El-Tamimi; Gerasimos Filippatos; Nicolas Girerd; Loreena Hill; Ewa Jankowska; Kamlesh Khunti; Basil S. Lewis; Brenda Moura; Offer Amir; Stefania Paolillo; Massimo Piepoli; Abdulla Shehab; Maggie Simpson; Hadi Skouri; Davide Stolfo; Carlo Gabriele Tocchetti; Cristiana Vitale; Maurizio Volterrani; Stephan von Haehling; Sven Wassmann; Mehmet Birhan Yilmaz; Juan Carlos Kaski; Dobromir Dobrev; Marco Metra; Giuseppe M.C. Rosano

doi:10.1002/ejhf.70090

Adherence to guideline-directed medical treatments in heart failure. A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on Cardiovascular Pharmacotherapy

Gianluigi Savarese
, Felix Lindberg
, Antonio Cannata
, Marianna Adamo
, Giuseppe Ambrosio
, Pietro Ameri
, Markus S. Anker
, Magnus Bäck
, Antoni Bayes-Genis
, Tuvia Ben Gal
, Frieder Braunschweig
, Ovidiu Chioncel
, Emilia D'Elia
, Hassan El-Tamimi
, Gerasimos Filippatos
, Nicolas Girerd
, Loreena Hill
, Ewa Jankowska
, Kamlesh Khunti
, Basil S. Lewis

Brenda Moura, Offer Amir, Stefania Paolillo, Massimo Piepoli, Abdulla Shehab, Maggie Simpson, Hadi Skouri, Davide Stolfo, Carlo Gabriele Tocchetti, Cristiana Vitale, Maurizio Volterrani, Stephan von Haehling, Sven Wassmann, Mehmet Birhan Yilmaz, Juan Carlos Kaski, Dobromir Dobrev, Marco Metra, Giuseppe M.C. Rosano

Karolinska Institutet
King's College Hospital NHS Foundation Trust
University of Brescia
University of Perugia
Italian National Institute for Cardiovascular Research – INRC
University of Genoa
San Martino Hospital Genoa
Charité – Universitätsmedizin Berlin
Université de Lorraine
Generalitat de Catalunya
Tel Aviv University
Carol Davila University of Medicine and Pharmacy
Papa Giovanni XXIII Hospital
University of Milan - Bicocca
Mohammed Bin Rashid University of Medicine and Health Sciences
National and Kapodistrian University of Athens
Ulster University
Wrocław Medical University
University of Leicester
Technion-Israel Institute of Technology
Porto Armed Forces Hospital
University of Porto
Hadassah University Medical Centre
University of Naples Federico II
IRCCS Policlinico San Donato
University of Milan
United Arab Emirates University
University of Edinburgh
University of Balamand
Sheikh Shakhbout Medical City
Azienda Sanitaria Universitaria Integrata di Udine
IRCCS San Raffaele Pisana - Roma
San Raffaele Open University of Rome
University of Göttingen
German Centre for Cardiovascular Research
Saarland University
Dokuz Eylul University
St. George's University of London
University of Duisburg-Essen
University of Montreal
Baylor College of Medicine
University of Rome

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Heart failure (HF) affects over 60 million individuals globally. Contemporary guideline-directed medical therapies (GDMT) reduce cardiovascular mortality and HF hospitalizations. However, medication non-adherence represents a critical barrier limiting real-world efficacy of GDMT. This scientific statement aims to provide a comprehensive framework for understanding, measuring, and addressing medication non-adherence in HF management across diverse healthcare settings. Addressing medication non-adherence requires systematic, multifaceted approaches targeting individual patient barriers while implementing system-level interventions. Polypills, digital monitoring platforms, enhanced patient education and empowerment, and multidisciplinary care models represent promising strategies to optimize therapeutic adherence and improve clinical outcomes in HF management.

Original language	English
Pages (from-to)	2716-2731
Number of pages	16
Journal	European Journal of Heart Failure
Volume	27
Issue number	12
Early online date	9 Nov 2025
DOIs	https://doi.org/10.1002/ejhf.70090
State	Published - Dec 2025
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2025 The Author(s). European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.

Keywords

Adherence
Digital
Education
Fixed-dose combinations
Guidelines
Heart failure
Multidisciplinary
Polypill

Access to Document

10.1002/ejhf.70090

Cite this

Savarese, G., Lindberg, F., Cannata, A., Adamo, M., Ambrosio, G., Ameri, P., Anker, M. S., Bäck, M., Bayes-Genis, A., Ben Gal, T., Braunschweig, F., Chioncel, O., D'Elia, E., El-Tamimi, H., Filippatos, G., Girerd, N., Hill, L., Jankowska, E., Khunti, K., ... Rosano, G. M. C. (2025). Adherence to guideline-directed medical treatments in heart failure. A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on Cardiovascular Pharmacotherapy. European Journal of Heart Failure, 27(12), 2716-2731. https://doi.org/10.1002/ejhf.70090

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title = "Adherence to guideline-directed medical treatments in heart failure. A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on Cardiovascular Pharmacotherapy",

abstract = "Heart failure (HF) affects over 60 million individuals globally. Contemporary guideline-directed medical therapies (GDMT) reduce cardiovascular mortality and HF hospitalizations. However, medication non-adherence represents a critical barrier limiting real-world efficacy of GDMT. This scientific statement aims to provide a comprehensive framework for understanding, measuring, and addressing medication non-adherence in HF management across diverse healthcare settings. Addressing medication non-adherence requires systematic, multifaceted approaches targeting individual patient barriers while implementing system-level interventions. Polypills, digital monitoring platforms, enhanced patient education and empowerment, and multidisciplinary care models represent promising strategies to optimize therapeutic adherence and improve clinical outcomes in HF management.",

keywords = "Adherence, Digital, Education, Fixed-dose combinations, Guidelines, Heart failure, Multidisciplinary, Polypill",

author = "Gianluigi Savarese and Felix Lindberg and Antonio Cannata and Marianna Adamo and Giuseppe Ambrosio and Pietro Ameri and Anker, \{Markus S.\} and Magnus B{\"a}ck and Antoni Bayes-Genis and \{Ben Gal\}, Tuvia and Frieder Braunschweig and Ovidiu Chioncel and Emilia D'Elia and Hassan El-Tamimi and Gerasimos Filippatos and Nicolas Girerd and Loreena Hill and Ewa Jankowska and Kamlesh Khunti and Lewis, \{Basil S.\} and Brenda Moura and Offer Amir and Stefania Paolillo and Massimo Piepoli and Abdulla Shehab and Maggie Simpson and Hadi Skouri and Davide Stolfo and Tocchetti, \{Carlo Gabriele\} and Cristiana Vitale and Maurizio Volterrani and \{von Haehling\}, Stephan and Sven Wassmann and Yilmaz, \{Mehmet Birhan\} and Kaski, \{Juan Carlos\} and Dobromir Dobrev and Marco Metra and Rosano, \{Giuseppe M.C.\}",

note = "Publisher Copyright: {\textcopyright} 2025 The Author(s). European Journal of Heart Failure published by John Wiley \& Sons Ltd on behalf of European Society of Cardiology.",

year = "2025",

month = dec,

doi = "10.1002/ejhf.70090",

language = "אנגלית",

volume = "27",

pages = "2716--2731",

journal = "European Journal of Heart Failure",

issn = "1388-9842",

publisher = "Oxford University Press",

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}

Savarese, G, Lindberg, F, Cannata, A, Adamo, M, Ambrosio, G, Ameri, P, Anker, MS, Bäck, M, Bayes-Genis, A, Ben Gal, T, Braunschweig, F, Chioncel, O, D'Elia, E, El-Tamimi, H, Filippatos, G, Girerd, N, Hill, L, Jankowska, E, Khunti, K, Lewis, BS, Moura, B, Amir, O, Paolillo, S, Piepoli, M, Shehab, A, Simpson, M, Skouri, H, Stolfo, D, Tocchetti, CG, Vitale, C, Volterrani, M, von Haehling, S, Wassmann, S, Yilmaz, MB, Kaski, JC, Dobrev, D, Metra, M & Rosano, GMC 2025, 'Adherence to guideline-directed medical treatments in heart failure. A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on Cardiovascular Pharmacotherapy', European Journal of Heart Failure, vol. 27, no. 12, pp. 2716-2731. https://doi.org/10.1002/ejhf.70090

Adherence to guideline-directed medical treatments in heart failure. A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on Cardiovascular Pharmacotherapy. / Savarese, Gianluigi; Lindberg, Felix; Cannata, Antonio et al.
In: European Journal of Heart Failure, Vol. 27, No. 12, 12.2025, p. 2716-2731.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Adherence to guideline-directed medical treatments in heart failure. A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on Cardiovascular Pharmacotherapy

AU - Savarese, Gianluigi

AU - Lindberg, Felix

AU - Cannata, Antonio

AU - Adamo, Marianna

AU - Ambrosio, Giuseppe

AU - Ameri, Pietro

AU - Anker, Markus S.

AU - Bäck, Magnus

AU - Bayes-Genis, Antoni

AU - Ben Gal, Tuvia

AU - Braunschweig, Frieder

AU - Chioncel, Ovidiu

AU - D'Elia, Emilia

AU - El-Tamimi, Hassan

AU - Filippatos, Gerasimos

AU - Girerd, Nicolas

AU - Hill, Loreena

AU - Jankowska, Ewa

AU - Khunti, Kamlesh

AU - Lewis, Basil S.

AU - Moura, Brenda

AU - Amir, Offer

AU - Paolillo, Stefania

AU - Piepoli, Massimo

AU - Shehab, Abdulla

AU - Simpson, Maggie

AU - Skouri, Hadi

AU - Stolfo, Davide

AU - Tocchetti, Carlo Gabriele

AU - Vitale, Cristiana

AU - Volterrani, Maurizio

AU - von Haehling, Stephan

AU - Wassmann, Sven

AU - Yilmaz, Mehmet Birhan

AU - Kaski, Juan Carlos

AU - Dobrev, Dobromir

AU - Metra, Marco

AU - Rosano, Giuseppe M.C.

PY - 2025/12

Y1 - 2025/12

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AB - Heart failure (HF) affects over 60 million individuals globally. Contemporary guideline-directed medical therapies (GDMT) reduce cardiovascular mortality and HF hospitalizations. However, medication non-adherence represents a critical barrier limiting real-world efficacy of GDMT. This scientific statement aims to provide a comprehensive framework for understanding, measuring, and addressing medication non-adherence in HF management across diverse healthcare settings. Addressing medication non-adherence requires systematic, multifaceted approaches targeting individual patient barriers while implementing system-level interventions. Polypills, digital monitoring platforms, enhanced patient education and empowerment, and multidisciplinary care models represent promising strategies to optimize therapeutic adherence and improve clinical outcomes in HF management.

KW - Adherence

KW - Digital

KW - Education

KW - Fixed-dose combinations

KW - Guidelines

KW - Heart failure

KW - Multidisciplinary

KW - Polypill

UR - https://www.scopus.com/pages/publications/105021334591

U2 - 10.1002/ejhf.70090

DO - 10.1002/ejhf.70090

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C2 - 41208145

AN - SCOPUS:105021334591

SN - 1388-9842

VL - 27

SP - 2716

EP - 2731

JO - European Journal of Heart Failure

JF - European Journal of Heart Failure

IS - 12

ER -

Savarese G, Lindberg F, Cannata A, Adamo M, Ambrosio G, Ameri P et al. Adherence to guideline-directed medical treatments in heart failure. A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on Cardiovascular Pharmacotherapy. European Journal of Heart Failure. 2025 Dec;27(12):2716-2731. Epub 2025 Nov 9. doi: 10.1002/ejhf.70090

Adherence to guideline-directed medical treatments in heart failure. A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on Cardiovascular Pharmacotherapy

Abstract

Bibliographical note

Keywords

Access to Document

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