Addin of Exogenous Estrogens To Improve Cervical Mucus Following Clomiphene Citrate Medication: Patient Selection

Medication with Clomiphene Citrate and its effects on the quality of cervical mucus and the addition of exogenous estrogens in order to suppress abnormal mucus secretion are controversial issues. We have prospectively studied a group of 19 anovulatory women who were treated with clomiphene citrate in order to characterize those patients most likely to respond to the addition of exogenous estrogens. On day 14 of the cycle, 17 β estradiol and cervical ‐re were measured and 1 mg estradiol benzoate was injected intramuscularly. Cervical scores were below 7 in 12 out of the 19 patients before estradiol benzoate administration. In these patients, 17 β estradiol rose from 751±541 to 1321±648 pg/ml (p<0.03).and cervical scores rose from 3.75±2.1 to 7.1±3.7 (p<0.0l), after estradiol benzoate administration. Patients with cervical scores of 8‐12 did not improve significantly. In the 12 patients with cervical scores below 7, those (n=6) with 17 β estradiol below 600pg/ml experienced a significant improvement in cervical score, in contrast to those (n=6) with 17 8 estradiol above 600pg/ml who had no improvement. The reduction in cervical mucus accomplished with clomiphene citrate can be further improved by adding exogenous estrogens, mainly in patients who have low 17 β estradiol levels concomitant with low cervical score. 1990 Acta Obstet Gynecol Scand