Adaptation of nanoarrays for the study of α-synuclein aggregation: preliminary results

HR Dietrich, den Doel RL van, W Hoyer, Oel W van, GL Lung, Y. Garini, T Jovin, IT Young

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

In previous publications we have shown that we can perform enzymatic reactions in nanoarrays by means of a microarray-reader based on a conventional microscope. In this publication we report on a modification of this system in order to monitor the aggregation kinetics of the natively unfolded protein α-synuclein. We describe the motivation for this development, the problems associated with the miniaturization of the aggregation assay, and the validation of our modifications.
Original languageAmerican English
Title of host publicationProceedings of the SPIE 5699
StatePublished - 2005

Bibliographical note

International Society for Optics and Photonics.;
Place of conference:San Jose ,CA

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