Abstract
In previous publications we have shown that we can perform enzymatic reactions in nanoarrays by means of a microarray-reader based on a conventional microscope. In this publication we report on a modification of this system in order to monitor the aggregation kinetics of the natively unfolded protein α-synuclein. We describe the motivation for this development, the problems associated with the miniaturization of the aggregation assay, and the validation of our modifications.
Original language | American English |
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Title of host publication | Proceedings of the SPIE 5699 |
State | Published - 2005 |
Bibliographical note
International Society for Optics and Photonics.;Place of conference:San Jose ,CA