Acute traumatic brain injuries and their management

Michael M. Krausz, Itamar Ashkenazi, Jean F. Soustiel

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Traumatic brain injuries (TBIs) represent the leading cause of death and morbidity in western countries. Since motor vehicle accidents are the leading cause of significant trauma, TBIs affect mostly young adults with increasing incidence and are responsible for a major social and economic burden. For decades, the mainstay of neurotrauma management has been represented by control of posttraumatic edema and raised intracranial pressure (ICP). With the emergence of a better understanding of the underlying cellular mechanisms responsible for the generation of secondary brain damage, the hope for the “magic bullet” has prompted the development of novel drugs. Encouraged by the promising results of basic research studies, clinical trials were initiated in an increasing number up to the mid-1990s. However, the high expectations raised by convincing laboratory data were not met by deceiving results that made pharmaceutical industry reluctant to support high-cost adventurous research that have repeatedly failed to significantly improve outcome of head-injured patients. Accordingly, the management of neurotrauma has focused back on optimization of neurointensive care and surgical treatment.

Original languageEnglish
Title of host publicationTrauma Surgery
Subtitle of host publicationVolume 1: Trauma Management, Trauma Critical Care, Orthopaedic Trauma and Neuro-Trauma
PublisherSpringer-Verlag Milan
Number of pages17
ISBN (Electronic)9788847054035
ISBN (Print)9788847054028
StatePublished - 1 Jan 2014
Externally publishedYes

Bibliographical note

Publisher Copyright:
© Springer-Verlag Italia 2014.


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