Abstract
Background and purpose: Cannabidiolic acid methyl ester (HU-580) was recently shown to reduce stress-induced anxiety-like behavior in rats. The aim of this study was to examine the antidepressant effect of HU-580 in two different rat models of depression. Experimental approach: Using the forced swim test (FST), we evaluated the effect of HU-580 in 43 Wistar–Kyoto (WKY) and 23 Flinders Sensitive Line (FSL) adult male rats. Key results: 1 mg/kg HU-580 reduced immobility and increased swimming in WKY rats, compared to vehicle-treated controls (p < 0.05). This dose exerted similar effects in FSL rats (p < 0.05). Conclusion and implications: This is the first report of antidepressant efficacy of HU-580. These findings expand the very limited existent results, suggesting that HU-580 is a potent anxiolytic agent. Taken together with its chemical stability, HU-580 emerges as a candidate for a future antidepressant medication.
| Original language | English |
|---|---|
| Pages (from-to) | 1-3 |
| Number of pages | 3 |
| Journal | Behavioural Brain Research |
| Volume | 351 |
| DOIs | |
| State | Published - 1 Oct 2018 |
Bibliographical note
Publisher Copyright:© 2018
Keywords
- Cannabidiolic acid methyl ester
- Flinders Sensitive Line (FSL)
- Forced swim test (FST)
- Genetic animal models of depression
- Major depression disorder (MDD)
- Wistar–Kyoto (WKY)
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