Activité gonadotrope d'un extrait d'urines de femmes en ménopause

R. Borth, B. Lunenfeld, H. de Watteville

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An extract from pooled postmenopausal urine has been investigated for its gonadotrophic activity. Dose-response curves have been constructed for its total gonadotrophic activity (stimulation of estrogen secretion as reflected by the uterine weight increase in immature mice) and for its ICSH activity (stimulation of androgen secretion as reflected by the ventral prostate weight increase in hypophysectomised immature rats). In hypophysectomised immature rats, the extract produced repair of the interstitial cells of the testes and complete spermatogenesis. It contains, therefore, FSH as well as ICSH activity in comparable amounts, a fact which opens up interesting therapeutic possibilities.

Original languageFrench
Pages (from-to)266-268
Number of pages3
Issue number6
StatePublished - Jun 1954
Externally publishedYes

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