Activité gonadotrope d'un extrait d'urines de femmes en ménopause

R. Borth, B. Lunenfeld, H. de Watteville

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

An extract from pooled postmenopausal urine has been investigated for its gonadotrophic activity. Dose-response curves have been constructed for its total gonadotrophic activity (stimulation of estrogen secretion as reflected by the uterine weight increase in immature mice) and for its ICSH activity (stimulation of androgen secretion as reflected by the ventral prostate weight increase in hypophysectomised immature rats). In hypophysectomised immature rats, the extract produced repair of the interstitial cells of the testes and complete spermatogenesis. It contains, therefore, FSH as well as ICSH activity in comparable amounts, a fact which opens up interesting therapeutic possibilities.

Original languageFrench
Pages (from-to)266-268
Number of pages3
JournalExperientia
Volume10
Issue number6
DOIs
StatePublished - Jun 1954
Externally publishedYes

Cite this