Activité gonadotrope d'un extrait d'urines de femmes en ménopause

R. Borth, B. Lunenfeld, G. Riotton, H. de Watteville

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In agreement with earlier observations on hypophysectomized male rats, a purified extract from pooled menopausal urine has been shown to contain follicle-stimulating (FSH) as well as luteinizing (LH) activity. Its administration to immature hypophysectomized female rats increased ovarian and uterine weights and induced follicle growth and the formation of corpora lutea. If the activity of the extract is measured in standardized units by bioassay in intact female mice using the uterine weight, the dose needed for corpus luteum formation in the hypophysectomized female rat seems to be approximately ten times higher than the dose producing interstitial cell repair and complete spermatogenesis in the hypophysectomized male.

Original languageFrench
Pages (from-to)115-117
Number of pages3
Issue number3
StatePublished - Mar 1957
Externally publishedYes

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