TY - JOUR
T1 - Activated protein C resistance can be associated with recurrent fetal loss
AU - Brenner, Benjamin
AU - Mandel, Hanna
AU - Lanir, Naomi
AU - Younis, Johnny
AU - Rothbart, Haim
AU - Ohel, Gonen
AU - Blumenfeld, Zeev
PY - 1997/6
Y1 - 1997/6
N2 - As thrombosis of placental vessels may result in recurrent fetal loss, we analysed 39 consecutive women with recurrent fetal loss of unknown cause for activated protein C resistance. Factor V Leiden (FVL) mutation (19 cases) or APC resistance without FVL (nine cases) were found among these 39 women. Evaluation of 128 pregnancies in 19 patients with factor V Leiden mutation and 56 gestations in nine women with acquired APC resistance, revealed over 50% first-trimester abortions and 17% late abortions. Intra-uterine fetal death occurred in nine out of 19 FVL patients (47%). Only 34 of 184 gestations (18%) in hereditary or acquired APC-resistance women resulted in a live birth, with 11 of the 34 (32%) being premature deliveries. These data suggest that, in some patients with recurrent fetal loss, hereditary and acquired APC resistance are potential causes of vascular placental insufficiency.
AB - As thrombosis of placental vessels may result in recurrent fetal loss, we analysed 39 consecutive women with recurrent fetal loss of unknown cause for activated protein C resistance. Factor V Leiden (FVL) mutation (19 cases) or APC resistance without FVL (nine cases) were found among these 39 women. Evaluation of 128 pregnancies in 19 patients with factor V Leiden mutation and 56 gestations in nine women with acquired APC resistance, revealed over 50% first-trimester abortions and 17% late abortions. Intra-uterine fetal death occurred in nine out of 19 FVL patients (47%). Only 34 of 184 gestations (18%) in hereditary or acquired APC-resistance women resulted in a live birth, with 11 of the 34 (32%) being premature deliveries. These data suggest that, in some patients with recurrent fetal loss, hereditary and acquired APC resistance are potential causes of vascular placental insufficiency.
KW - factor V Leiden
KW - placental thrombosis
KW - pregnancy
KW - protein C resistance
UR - http://www.scopus.com/inward/record.url?scp=0031004309&partnerID=8YFLogxK
U2 - 10.1046/j.1365-2141.1997.882901.x
DO - 10.1046/j.1365-2141.1997.882901.x
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C2 - 9207398
AN - SCOPUS:0031004309
SN - 0007-1048
VL - 97
SP - 551
EP - 554
JO - British Journal of Haematology
JF - British Journal of Haematology
IS - 3
ER -