Abstract
Structured illumination microscopy is an optical method to increase the spatial resolution of wide-field fluorescence imaging beyond the diffraction limit by applying a spatially structured illumination light. Here, we extend this concept to facilitate super-resolution ultrasound imaging by manipulating the transmitted sound field to encode the high spatial frequencies into the observed image through aliasing. Post processing is applied to precisely shift the spectral components to their proper positions in k-space and effectively double the spatial resolution of the reconstructed image compared to one-way focusing. The method has broad application, including the detection of small lesions for early cancer diagnosis, improving the detection of the borders of organs and tumors, and enhancing visualization of vascular features. The method can be implemented with conventional ultrasound systems, without the need for additional components. The resulting image enhancement is demonstrated with both test objects and ex vivo rat metacarpals and phalanges.
Original language | English |
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Article number | 3 |
Journal | Communications Biology |
Volume | 1 |
Issue number | 1 |
DOIs | |
State | Published - 1 Dec 2018 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2018, The Author(s).
Funding
This work was supported by the National Institutes of Health (NIHR01CA112356, NIHR01CA199658, NIHR01CA211602, NIHR01CA210553, and NIHR01CA134659).
Funders | Funder number |
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National Institutes of Health | NIHR01CA134659, NIHR01CA210553, NIHR01CA112356, NIHR01CA211602 |
National Cancer Institute | R01CA199658 |