Acetylcholinesterase and Aβ aggregation inhibition by heterometallic ruthenium(II)-platinum(II) polypyridyl complexes

Nilima A. Vyas; Sushma B. Singh; Avinash S. Kumbhar; Dnyanesh S. Ranade; Gulshan R. Walke; Prasad P. Kulkarni; Vinod Jani; Uddhavesh B. Sonavane; Rajendra R. Joshi; Srikanth Rapole

doi:10.1021/acs.inorgchem.8b00091

Acetylcholinesterase and Aβ aggregation inhibition by heterometallic ruthenium(II)-platinum(II) polypyridyl complexes

Nilima A. Vyas, Sushma B. Singh, Avinash S. Kumbhar, Dnyanesh S. Ranade, Gulshan R. Walke, Prasad P. Kulkarni, Vinod Jani, Uddhavesh B. Sonavane, Rajendra R. Joshi, Srikanth Rapole

University of Pune

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Two heteronuclear ruthenium(II)-platinum(II) complexes [Ru(bpy)₂(BPIMBp)PtCl₂]²⁺ (3) and [Ru(phen)₂(BPIMBp)PtCl₂]²⁺ (4), where bpy = 2,2′-bipyridine, phen = 1,10-phenanthroline, and BPIMBp = 1,4′-bis[(2-pyridin-2-yl)-1H-imidazol-1-ylmethyl]-1,1′-biphenyl, have been designed and synthesized from their mononuclear precursors [Ru(bpy)₂(BPIMBp)]²⁺ (1) and [Ru(phen)₂(BPIMBp)]²⁺ (2) as multitarget molecules for Alzheimer’s disease (AD). The inclusion of the cis-PtCl₂ moiety facilitates the covalent interaction of Ru(II) polypyridyl complexes with amyloid β (Aβ) peptide. These multifunctional complexes act as inhibitors of acetylcholinesterase (AChE), Aβ aggregation, and Cu-induced oxidative stress and protect neuronal cells against Aβ-toxicity. The study highlights the design of metal based anti-Alzheimer’s disease (AD) systems.

Original language	English
Pages (from-to)	7524-7535
Number of pages	12
Journal	Inorganic Chemistry
Volume	57
Issue number	13
DOIs	https://doi.org/10.1021/acs.inorgchem.8b00091
State	Published - 2 Jul 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
Copyright © 2018 American Chemical Society.

Funding

NAV acknowledges Department of Science and Technology (DST), New Delhi, India, (SR/WOS-A/CS-63/2010) for funding. ASK and SBS acknowledge Department of Science and Technology (DST), New Delhi, India, for financial support under the scheme SR/S1/IC-25/2010. GRW thanks CSIR, Government of India for SRF. This work was supported by the funds from Department of Science and Technology, New Delhi, India (EMR/2014/001235). The authors thank Mr. Umesh Kasbe, CIF, SPPU for NMR experiments.

Funders	Funder number
Department of Science and Technology, Ministry of Science and Technology, India	SR/WOS-A/CS-63/2010, SR/S1/IC-25/2010
Council of Scientific and Industrial Research, India	EMR/2014/001235
Department of Science and Technology, Government of Kerala

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title = "Acetylcholinesterase and Aβ aggregation inhibition by heterometallic ruthenium(II)-platinum(II) polypyridyl complexes",

abstract = "Two heteronuclear ruthenium(II)-platinum(II) complexes [Ru(bpy)2(BPIMBp)PtCl2]2+ (3) and [Ru(phen)2(BPIMBp)PtCl2]2+ (4), where bpy = 2,2′-bipyridine, phen = 1,10-phenanthroline, and BPIMBp = 1,4′-bis[(2-pyridin-2-yl)-1H-imidazol-1-ylmethyl]-1,1′-biphenyl, have been designed and synthesized from their mononuclear precursors [Ru(bpy)2(BPIMBp)]2+ (1) and [Ru(phen)2(BPIMBp)]2+ (2) as multitarget molecules for Alzheimer{\textquoteright}s disease (AD). The inclusion of the cis-PtCl2 moiety facilitates the covalent interaction of Ru(II) polypyridyl complexes with amyloid β (Aβ) peptide. These multifunctional complexes act as inhibitors of acetylcholinesterase (AChE), Aβ aggregation, and Cu-induced oxidative stress and protect neuronal cells against Aβ-toxicity. The study highlights the design of metal based anti-Alzheimer{\textquoteright}s disease (AD) systems.",

author = "Vyas, {Nilima A.} and Singh, {Sushma B.} and Kumbhar, {Avinash S.} and Ranade, {Dnyanesh S.} and Walke, {Gulshan R.} and Kulkarni, {Prasad P.} and Vinod Jani and Sonavane, {Uddhavesh B.} and Joshi, {Rajendra R.} and Srikanth Rapole",

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AU - Singh, Sushma B.

AU - Kumbhar, Avinash S.

AU - Ranade, Dnyanesh S.

AU - Walke, Gulshan R.

AU - Kulkarni, Prasad P.

AU - Jani, Vinod

AU - Sonavane, Uddhavesh B.

AU - Joshi, Rajendra R.

AU - Rapole, Srikanth

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AB - Two heteronuclear ruthenium(II)-platinum(II) complexes [Ru(bpy)2(BPIMBp)PtCl2]2+ (3) and [Ru(phen)2(BPIMBp)PtCl2]2+ (4), where bpy = 2,2′-bipyridine, phen = 1,10-phenanthroline, and BPIMBp = 1,4′-bis[(2-pyridin-2-yl)-1H-imidazol-1-ylmethyl]-1,1′-biphenyl, have been designed and synthesized from their mononuclear precursors [Ru(bpy)2(BPIMBp)]2+ (1) and [Ru(phen)2(BPIMBp)]2+ (2) as multitarget molecules for Alzheimer’s disease (AD). The inclusion of the cis-PtCl2 moiety facilitates the covalent interaction of Ru(II) polypyridyl complexes with amyloid β (Aβ) peptide. These multifunctional complexes act as inhibitors of acetylcholinesterase (AChE), Aβ aggregation, and Cu-induced oxidative stress and protect neuronal cells against Aβ-toxicity. The study highlights the design of metal based anti-Alzheimer’s disease (AD) systems.

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Acetylcholinesterase and Aβ aggregation inhibition by heterometallic ruthenium(II)-platinum(II) polypyridyl complexes

Abstract

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Funding

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