Acetyl chloride-methanol as a convenient reagent for: A) quantitative formation of amine hydrochlorides; B) carboxylate ester formation; C) mild removal of N-t-Boc-protective group

Ayelet Nudelman; Yosi Bechor; Eliezer Falb; Bilha Fischer; Barry A. Wexler; Abraham Nudelman

doi:10.1080/00397919808005101

Acetyl chloride-methanol as a convenient reagent for: A) quantitative formation of amine hydrochlorides; B) carboxylate ester formation; C) mild removal of N-t-Boc-protective group

Ayelet Nudelman
, Yosi Bechor
, Eliezer Falb
, Bilha Fischer
, Barry A. Wexler
, Abraham Nudelman

Department of Chemistry

Bar-Ilan University
DuPont

Research output: Contribution to journal › Article › peer-review

109 Scopus citations

Abstract

Hydrogen chloride quatitativaly generated in situ by the addition of acetyl chloride to alcoholic solutions is a useful reagent for carboxylic acid esterification, N-t-Boc deprotection and phosphoramide solvolysis reactions.

Original language	English
Pages (from-to)	471-474
Number of pages	4
Journal	Synthetic Communications
Volume	28
Issue number	3
DOIs	https://doi.org/10.1080/00397919808005101
State	Published - 1998

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10.1080/00397919808005101

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title = "Acetyl chloride-methanol as a convenient reagent for: A) quantitative formation of amine hydrochlorides; B) carboxylate ester formation; C) mild removal of N-t-Boc-protective group",

abstract = "Hydrogen chloride quatitativaly generated in situ by the addition of acetyl chloride to alcoholic solutions is a useful reagent for carboxylic acid esterification, N-t-Boc deprotection and phosphoramide solvolysis reactions.",

author = "Ayelet Nudelman and Yosi Bechor and Eliezer Falb and Bilha Fischer and Wexler, \{Barry A.\} and Abraham Nudelman",

year = "1998",

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T2 - A) quantitative formation of amine hydrochlorides; B) carboxylate ester formation; C) mild removal of N-t-Boc-protective group

AU - Nudelman, Ayelet

AU - Bechor, Yosi

AU - Falb, Eliezer

AU - Fischer, Bilha

AU - Wexler, Barry A.

AU - Nudelman, Abraham

PY - 1998

Y1 - 1998

N2 - Hydrogen chloride quatitativaly generated in situ by the addition of acetyl chloride to alcoholic solutions is a useful reagent for carboxylic acid esterification, N-t-Boc deprotection and phosphoramide solvolysis reactions.

AB - Hydrogen chloride quatitativaly generated in situ by the addition of acetyl chloride to alcoholic solutions is a useful reagent for carboxylic acid esterification, N-t-Boc deprotection and phosphoramide solvolysis reactions.

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DO - 10.1080/00397919808005101

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JO - Synthetic Communications

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ER -

Acetyl chloride-methanol as a convenient reagent for: A) quantitative formation of amine hydrochlorides; B) carboxylate ester formation; C) mild removal of N-t-Boc-protective group

Abstract

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