Acetyl chloride-methanol as a convenient reagent for: A) quantitative formation of amine hydrochlorides; B) carboxylate ester formation; C) mild removal of N-t-Boc-protective group

Ayelet Nudelman, Yosi Bechor, Eliezer Falb, Bilha Fischer, Barry A. Wexler, Abraham Nudelman

Research output: Contribution to journalArticlepeer-review

91 Scopus citations

Abstract

Hydrogen chloride quatitativaly generated in situ by the addition of acetyl chloride to alcoholic solutions is a useful reagent for carboxylic acid esterification, N-t-Boc deprotection and phosphoramide solvolysis reactions.

Original languageEnglish
Pages (from-to)471-474
Number of pages4
JournalSynthetic Communications
Volume28
Issue number3
DOIs
StatePublished - 1998

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