Acetyl chloride-methanol as a convenient reagent for: A) quantitative formation of amine hydrochlorides; B) carboxylate ester formation; C) mild removal of N-t-Boc-protective group

Ayelet Nudelman, Yosi Bechor, Eliezer Falb, Bilha Fischer, Barry A. Wexler, Abraham Nudelman

Research output: Contribution to journalArticlepeer-review

98 Scopus citations

Abstract

Hydrogen chloride quatitativaly generated in situ by the addition of acetyl chloride to alcoholic solutions is a useful reagent for carboxylic acid esterification, N-t-Boc deprotection and phosphoramide solvolysis reactions.

Original languageEnglish
Pages (from-to)471-474
Number of pages4
JournalSynthetic Communications
Volume28
Issue number3
DOIs
StatePublished - 1998

Fingerprint

Dive into the research topics of 'Acetyl chloride-methanol as a convenient reagent for: A) quantitative formation of amine hydrochlorides; B) carboxylate ester formation; C) mild removal of N-t-Boc-protective group'. Together they form a unique fingerprint.

Cite this