Acceptance and commitment therapy for episodic migraine: Rationale and design of a pilot randomized controlled trial

C. A. Bernstein; J. P. Connor; E. S. Vilsmark; M. Paschali; L. Rozenkrantz; P. M. Rist; P. M. Wayne; A. Lazaridou

doi:10.1016/j.cct.2022.106907

Acceptance and commitment therapy for episodic migraine: Rationale and design of a pilot randomized controlled trial

C. A. Bernstein, J. P. Connor, E. S. Vilsmark, M. Paschali, L. Rozenkrantz, P. M. Rist, P. M. Wayne, A. Lazaridou

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Migraine is a debilitating disorder with limited pharmacological options. Many migraine medications can have intolerable side effects leading patients to seek complementary and integrative health (CIM) approaches for treatment. One option that is growing in popularity and evidence is Acceptance and Commitment Therapy (ACT), a mindfulness-based therapy. The purpose of this paper is to describe how ACT may be an effective modality integrated into the treatment of migraine and to describe the design of a pilot study of ACT for migraine. First, we review the research and the promise of mindfulness therapies for the treatment of migraine. Then, we describe how ACT differs from other mindfulness therapies for migraine and why it can be a promising option for these patients. Finally, we summarize the design of a pilot study designed to determine the feasibility of performing a future fully powered study to determine the effectiveness of ACT on migraine frequency and disability. This pilot study includes unique features, including a remotely-delivered ACT intervention and the measurement of cortisol levels before and after the intervention.

Original language	English
Article number	106907
Journal	Contemporary Clinical Trials
Volume	121
DOIs	https://doi.org/10.1016/j.cct.2022.106907
State	Published - Oct 2022
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2022 Elsevier Inc.

Funding

Bernstein CA was supported by the Crimson Lion Foundation . Rist PM was supported by K01 HL128791 . Wayne PM was supported by K24AT009282 from NCCIH .

Funders	Funder number
Crimson Lion Foundation
National Heart, Lung, and Blood Institute	K01HL128791
National Center for Complementary and Integrative Health	K24AT009282

Keywords

Acceptance and commitment therapy
Chronic pain management
Migraine
Mindfulness
Mindfulness-based cognitive therapy
Randomized controlled trial

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10.1016/j.cct.2022.106907

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title = "Acceptance and commitment therapy for episodic migraine: Rationale and design of a pilot randomized controlled trial",

abstract = "Migraine is a debilitating disorder with limited pharmacological options. Many migraine medications can have intolerable side effects leading patients to seek complementary and integrative health (CIM) approaches for treatment. One option that is growing in popularity and evidence is Acceptance and Commitment Therapy (ACT), a mindfulness-based therapy. The purpose of this paper is to describe how ACT may be an effective modality integrated into the treatment of migraine and to describe the design of a pilot study of ACT for migraine. First, we review the research and the promise of mindfulness therapies for the treatment of migraine. Then, we describe how ACT differs from other mindfulness therapies for migraine and why it can be a promising option for these patients. Finally, we summarize the design of a pilot study designed to determine the feasibility of performing a future fully powered study to determine the effectiveness of ACT on migraine frequency and disability. This pilot study includes unique features, including a remotely-delivered ACT intervention and the measurement of cortisol levels before and after the intervention.",

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year = "2022",

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AU - Connor, J. P.

AU - Vilsmark, E. S.

AU - Paschali, M.

AU - Rozenkrantz, L.

AU - Rist, P. M.

AU - Wayne, P. M.

AU - Lazaridou, A.

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AB - Migraine is a debilitating disorder with limited pharmacological options. Many migraine medications can have intolerable side effects leading patients to seek complementary and integrative health (CIM) approaches for treatment. One option that is growing in popularity and evidence is Acceptance and Commitment Therapy (ACT), a mindfulness-based therapy. The purpose of this paper is to describe how ACT may be an effective modality integrated into the treatment of migraine and to describe the design of a pilot study of ACT for migraine. First, we review the research and the promise of mindfulness therapies for the treatment of migraine. Then, we describe how ACT differs from other mindfulness therapies for migraine and why it can be a promising option for these patients. Finally, we summarize the design of a pilot study designed to determine the feasibility of performing a future fully powered study to determine the effectiveness of ACT on migraine frequency and disability. This pilot study includes unique features, including a remotely-delivered ACT intervention and the measurement of cortisol levels before and after the intervention.

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Acceptance and commitment therapy for episodic migraine: Rationale and design of a pilot randomized controlled trial

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Keywords

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