Absorbable biopolymers derived from dimer fatty acids

Abraham J. Domb, Manoj Maniar

Research output: Contribution to journalArticlepeer-review

104 Scopus citations


A new class of aliphatic copolyanhydrides was synthesized from nonlinear hydrophobic dimers (FAD) of erucic acid and sebacic acid which possessed the desired physico‐chemical and mechanical properties for use as a carrier for drugs. The polymers were synthesized by melt condensation to yield film‐forming polymers with molecular weights of 250,000. The copolymer composition was determined by 1H‐NMR and gravimetric methods. In vitro degradation studies showed that these polymers degrade following a first‐order kinetics with a rapid degradation in the first 10 days leaving a residue which is mostly the FAD comonomer. The drug release from the polymer also followed a first‐order kinetics which correlates with the degradation process of the polymer. Drugs like carboplatin, methotrexate, tetracycline, and gentamicin were released in vitro for over 2 weeks and in some cases over 6 weeks. In vivo biocompatibility tests in rats and rabbits in the brain, muscle, and subcutaneously, demonstrated their toxicological inertness and biodegradability. The 1 : 1 copolymer of FAD : SA was selected as a carrier for various applications including a gentamicin‐releasing implant which is now undergoing human clinical trials for the treatment of osteomyelitis. © 1993 John Wiley & Sons, Inc.

Original languageEnglish
Pages (from-to)1275-1285
Number of pages11
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Issue number5
StatePublished - Apr 1993
Externally publishedYes


  • biodegradable polymers
  • dimer fatty acid
  • polyanhydride


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