Absence of the α2c-adrenoceptor Del322-325 allele is associated with increased mortality in patients with chronic systolic heart failure

Offer Amir, Yoav Smith, Barak Zafrir, Naiel Azzam, Basil S. Lewis, Fuad Fares

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4 Scopus citations

Abstract

Objective: The Del322-325 polymorphism of the α2c- adrenoceptor is considered to be a possible risk factor for heart failure (HF). We investigated the possible clinical association between the presence or absence of the deletion allele and mortality. Methods and Results: Of 261 chronic systolic HF patients evaluated, 216 (83%) carried no α2c-adrenoceptor Del322-325 alleles (designated II); 28 patients (11%) were heterozygous (ID) and 17 patients (6%) homozygous (DD) for the deletion. Similar genetic distribution of α2c-adrenoceptor Del322-325 subgroups was found in a control group of 96 healthy individuals. Mortality was significantly higher in HF patients in whom the deletion allele was absent than in HF patients who carried it: 67 (31%) patients in the II subgroup died compared with 7 (15.5%) in the ID/DD subgroup (P =.01). The odds ratio for death in HF patients who carried no α2c-adrenoceptor Del322-325 alleles compared with HF patients with ≥1 allele was 2.45 (95% confidence interval 1.045.74). There were no differences in other relevant clinical parameters between the 2 subgroups of HF patients. Conclusions: The mortality rate of chronic systolic HF patients carrying no α2c- adrenoceptor Del322-325 alleles was significantly higher (almost 2.5-fold) than that of HF patients carrying ≥1 allele.

Original languageEnglish
Pages (from-to)925-929
Number of pages5
JournalJournal of Cardiac Failure
Volume18
Issue number12
DOIs
StatePublished - Dec 2012
Externally publishedYes

Keywords

  • Heart failure
  • mortality
  • norepinephrine
  • α2c Del 322-325 polymorphism

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