TY - JOUR
T1 - Abolishment of the positive feedback mechanism
T2 - A criterion for temporary medical hypophysectomy by LH-RH agonist
AU - Shadmi, A. L.
AU - Lunenfeld, B.
AU - Bahan, C.
AU - Kokia, E.
AU - Pariente, C.
AU - Blankstein, J.
PY - 1987/3
Y1 - 1987/3
N2 - The hypothalamic pituitary axis was studied in patients with an abnormal pattern of gonadotropin release during chronic treatment with LH-RH agonist. Two patients had PCOD and the third demonstrated the early luteinization phenomenon. Following a well-defined gonadotropin rise with initiation of LH-RH treatment, no further response was noted. Stabilization of the LH:FSH ratio in PCOD patients was noted after 4 weeks of treatment. Administration of both native LH-RH (100 μg) and intravenous pulsatile LH-RH did not evoke any rise in LH. In addition to the above LH-RH challenges, the positive feedback was examined by administration of estradiol benzoate (EB). The study demonstrated that, although the pituitary did not respond to any LH-RH challenge, it may still respond by a rise in LH following EB administration. Both functions of the hypothalamic pituitary axis should be examined in order to determine the state of medical hypophysectomy.
AB - The hypothalamic pituitary axis was studied in patients with an abnormal pattern of gonadotropin release during chronic treatment with LH-RH agonist. Two patients had PCOD and the third demonstrated the early luteinization phenomenon. Following a well-defined gonadotropin rise with initiation of LH-RH treatment, no further response was noted. Stabilization of the LH:FSH ratio in PCOD patients was noted after 4 weeks of treatment. Administration of both native LH-RH (100 μg) and intravenous pulsatile LH-RH did not evoke any rise in LH. In addition to the above LH-RH challenges, the positive feedback was examined by administration of estradiol benzoate (EB). The study demonstrated that, although the pituitary did not respond to any LH-RH challenge, it may still respond by a rise in LH following EB administration. Both functions of the hypothalamic pituitary axis should be examined in order to determine the state of medical hypophysectomy.
UR - http://www.scopus.com/inward/record.url?scp=0023302923&partnerID=8YFLogxK
U2 - 10.3109/09513598709082691
DO - 10.3109/09513598709082691
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C2 - 2972166
AN - SCOPUS:0023302923
SN - 0951-3590
VL - 1
SP - 1
EP - 11
JO - Gynecological Endocrinology
JF - Gynecological Endocrinology
IS - 1
ER -